Prostaglandins affect the central nervous system to produce hyperglycemia in rats.
Prostaglandins affect the central nervous system to produce hyperglycemia in rats.
复制标题
前列腺素影响中枢神经系统，导致大鼠出现高血糖。
DOI：
10.1210/endo-121-1-36
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发表时间：
1987
期刊：
影响因子：
4.8
通讯作者：
N. Sakamoto
中科院分区：
文献类型：
--
作者：
A. Yatomi;A. Iguchi;S. Yanagisawa;H. Matsunaga;I. Niki;N. Sakamoto
在大鼠中研究了前列腺素（PG）对中枢神经系统血糖稳态调节的影响。将物质注射到麻醉大鼠的第三脑室，同时记录直肠温度和肝静脉血浆葡萄糖浓度。 PGD2、E1、E2 和 F2 α 的立体定位显微注射产生高血糖和高热。高血糖中效力的相对顺序（PGF2α大于D2大于E1大于E2）与高热的相对顺序（PGE2大于F2α大于E1大于D2）不一致，这表明高血糖是对高热的主要而非继发反应。注射PGF2α导致肝静脉血浆葡萄糖水平呈剂量依赖性（5-200微克）增加。将 PGF2 α（50 微克）注射到皮质或全身静脉中都不会引起高血糖。将PGF2α注射到心室不仅导致葡萄糖增加，而且肝静脉血浆中的胰高血糖素、肾上腺素和去甲肾上腺素也增加。然而，尽管仍然观察到血浆葡萄糖水平增加，但通过股静脉持续输注生长抑素完全阻止了施用PGF2α后胰高血糖素的增加。 PGF2α诱导的高血糖在肾上腺髓质大鼠中没有发生。静脉注射纳洛酮或普萘洛尔不影响高血糖，但酚妥拉明显着阻止PGF2α的高血糖作用。这些结果表明，心室内PGF2α通过增加肾上腺髓质的肾上腺素分泌来影响中枢神经系统以产生高血糖。
The influence of prostaglandins (PG) on central nervous system regulation of blood sugar homeostasis was studied in rats. Substances were injected into the third cerebral ventricle of anesthetized rats while rectal temperature and hepatic venous plasma glucose concentration were recorded. Stereotaxic microinjection of PGD2, E1, E2, and F2 alpha produced hyperglycemia and hyperthermia. The relative order of potency in hyperglycemia, PGF2 alpha greater than D2 greater than E1 greater than E2, was not consistent with that of hyperthermia, PGE2 greater than F2 alpha greater than E1 greater than D2, which suggests that hyperglycemia was a primary, not secondary, response to hyperthermia. Injection of PGF2 alpha caused a dose dependent (5-200 micrograms) increase in the hepatic venous plasma glucose level. Neither the injection of PGF2 alpha (50 micrograms) into the cortex nor into the systemic vein caused hyperglycemia. The injection of PGF2 alpha into the ventricle resulted in the increase of not only glucose, but also glucagon, epinephrine, and norephinephrine in the hepatic venous plasma. However, constant infusion of somatostatin through the femoral vein completely prevented the increase of glucagon after administration of PGF2 alpha, although the increase of plasma glucose level was still observed. PGF2 alpha-induced hyperglycemia did not occur in adrenodemedullated rats. Intravenous injection of naloxone or propranolol did not affect the hyperglycemia, but phentolamine significantly prevented the hyperglycemic effect of PGF2 alpha. These results suggest that intraventricular PGF2 alpha affects the central nervous system to produce hyperglycemia by increasing epinephrine secretion from the adrenal medulla.