Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism
Functional subdivisions of the hypothalamus using areal parcellation and their signal changes related to glucose metabolism
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DOI：
10.1016/j.neuroimage.2017.08.056
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发表时间：
2017-11-15
期刊：
影响因子：
5.7
通讯作者：
Konishi, Seiki
中科院分区：
文献类型：
--
作者：
Osada, Takahiro;Suzuki, Ruriko;Konishi, Seiki
下丘脑由许多核团组成，被认为是各种自主神经功能的最高中心。虽然下丘脑的每个核团都有不同的功能，但在核团水平上研究人类下丘脑仍然很困难。在目前的高分辨率功能磁共振成像研究中，我们利用面积parcellation来区分个人核在人类下丘脑的基础上，休息状态的功能连接的面积配置文件。区域包裹检测到10个病灶，预计代表下丘脑核，病灶的位置与以前的组织学研究中确定的下丘脑核一致。感兴趣区域（ROI）分析显示葡萄糖摄入后大脑活动发生了对比变化：下丘脑腹内侧核减少，下丘脑外侧区增加，与血糖增加平行。此外，弓状核的脑活动减少预示着摄入葡萄糖后的前10分钟内血胰岛素的升高。这些结果表明，下丘脑核团可以pueretically确定使用面积parcellation，和人类下丘脑核团的ROI分析是有用的，为未来的科学和临床研究的自主神经功能。
The hypothalamus consists of numerous nuclei, and is regarded as the highest center for various autonomic functions. Although each hypothalamic nucleus implements a distinct function, it remains difficult to investigate the human hypothalamus at the nucleus level. In the present high-resolution functional MRI study, we utilized areal parcellation to discriminate individual nuclei in the human hypothalamus based on areal profiles of resting-state functional connectivity. The areal parcellation detected ten foci that were expected to represent hypothalamic nuclei, and the locations of the foci were consistent with those of the hypothalamic nuclei identified in previous histological studies. Regions of interest (ROI) analyses revealed contrasting brain activity changes following glucose ingestion: decrease in the ventromedial hypothalamic nucleus and increase in the lateral hypothalamic area in parallel with blood glucose increase. Moreover, decreased brain activity in the arcuate nucleus predicted future elevation of blood insulin during the first 10 min after glucose ingestion. These results suggest that the hypothalamic nuclei can putatively be determined using areal parcellation, and that the ROI analysis of the human hypothalamic nuclei is useful for future scientific and clinical investigations into the autonomic functions.