DEVELOPMENTAL EXPRESSION OF MESSENGER-RNAS FROM A RAT C-ERBA GENOMIC LOCUS
DEVELOPMENTAL EXPRESSION OF MESSENGER-RNAS FROM A RAT C-ERBA GENOMIC LOCUS
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DOI：
10.1016/0006-291x(92)90652-2
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发表时间：
1992-04-30
影响因子：
3.1
通讯作者：
NIKODEM, VM
中科院分区：
文献类型：
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作者：
JANNINI, EA;MITSUHASHI, T;NIKODEM, VM
甲状腺激素受体α基因选择性剪接产生α受体和不结合甲状腺激素的变体。另一个α样受体（Rev-erbAα）转录在相反的链上，并与独特的变体序列重叠。大鼠脑内α受体在出生后5-15天达到高峰。从出生前2天到老年，变异仍然很高。Rev-erbAα mRNA在出生后5天开始增加，在成年期达到最大值。甲状腺激素减少和甲状腺功能减退症增加这3个信息的水平。我们的结论是，这些信息的水平同样由甲状腺激素控制，但有不同的个体发育控制。Rev-erbA α与变体的潜在反义配对在体内未观察到功能结果。
The thyroid hormone receptor α gene is alternatively spliced to give the α receptor and a variant which does not bind thyroid hormones. An additional alpha-like receptor (Rev-erbAα) is transcribed on the opposite strand and overlaps the unique variant sequence. The α receptor in rat brain reaches peak levels 5–15 days after birth. The variant remains high from 2 days before birth to old age. The Rev-erbAα mRNA increases beginning 5 days after birth, maximizing in adulthood. Thyroid hormone decreases and hypothyroidism increases the level of these 3 messages. We conclude that the levels of these messages are similarly controlled by thyroid hormone but have different ontogenetic controls. No functional results can be seen in vivo from potential anti sense pairing of Rev-erbA α with the variant.