Molecular characterization of chicken-derived genotype VIId Newcastle disease virus isolates in China during 2005-2012 reveals a new length in hemagglutinin-neuraminidase
Molecular characterization of chicken-derived genotype VIId Newcastle disease virus isolates in China during 2005-2012 reveals a new length in hemagglutinin-neuraminidase
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DOI：
10.1016/j.meegid.2013.12.003
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Zhang, Guo-zhong
中科院分区：
文献类型：
--
作者：
Zhang, Yuan-yuan;Shao, Meng-yu;Zhang, Guo-zhong
纽卡斯尔病（Newcastle disease，ND）是世界上最重要的家禽疾病之一，给世界养禽业造成严重的经济损失。虽然所有的纽卡斯尔病病毒（NDV）分离株属于单一血清型，但不同NDV分离株之间存在显著的遗传多样性。本文报道了我国流行的23株Ⅱ类新城疫病毒VIId基因型强毒株的分子特征。系统发育构建和分析表明，存在明显的基因组和氨基酸的差异，明确区分这些分离物从其他典型的NDV基因型和疫苗株。我们还报告了一个新的582个氨基酸的血凝素神经氨酸酶基因型VII NDV株。本研究首次系统地研究了我国NDV的主要流行毒株，为进一步了解我国流行的Ⅱ类VIId基因型NDV的遗传特性提供了新的信息。(C)2013年爱思唯尔B。V.保留所有权利。
Newcastle disease (ND) is one of the most important diseases of poultry, and causes severe economic losses in the global poultry industry. Although all Newcastle disease virus (NDV) isolates belong to a single serotype, significant genetic diversity has been described between different NDV isolates. Here, we report the molecular characterization of 23 virulent genotype VIId NDV isolates of class II circulating in China. Phylogenetic construction and analysis revealed the existence of distinctly genomic and amino acid differences that clearly distinguished these isolates from other typical NDV genotypes and vaccine strains. We also report a new 582-amino-acid hemagglutinin-neuraminidase in genotype VII NDV strains. This is believed to be the first study to investigate systematically the most predominant NDV strains, and provides more information on the genetic nature of genotype VIId NDV of class II circulating in China. (C) 2013 Elsevier B. V. All rights reserved.