Persistent infection of rat insulinoma cells with Coxsackie B4 virus. Brief report.
Persistent infection of rat insulinoma cells with Coxsackie B4 virus. Brief report.
复制标题
柯萨奇 B4 病毒持续感染大鼠胰岛素瘤细胞。
DOI：
10.1007/bf01310551
复制
发表时间：
1986
影响因子：
2.7
通讯作者：
Wilfert,CM
中科院分区：
文献类型：
--
作者：
FrankJr,JA;Schmidt,EV;Smith,RE;Wilfert,CM
Plaque purified Coxsackie B4 virus (CB4) caused a persistent infection of rat insulinoma (RIN) cells which lasted for the 70 day observation period. Infectious virus was produced and no cytopathic effect was observed. Indirect immunofluorescence and infectious center assays demonstrated that a majority of RIN cells were infected. Defective interfering particles were not demonstrated. Despite persistent infection, insulin synthesis by RIN cells was not altered.
