Regional difference in prefrontal oxygenation before and during overground walking in humans: a wearable multichannel NIRS study
Regional difference in prefrontal oxygenation before and during overground walking in humans: a wearable multichannel NIRS study
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DOI：
10.1152/ajpregu.00192.2021
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发表时间：
2022-01-01
影响因子：
2.8
通讯作者：
Matsukawa, Kanji
中科院分区：
文献类型：
--
作者：
Asahara, Ryota;Ishii, Kei;Matsukawa, Kanji
使用无线多通道近红外光谱，区域差异在前额叶皮层（PFC）的皮层活动进行了检查之前和在地上行走，并在响应速度和认知需求的变化。氧合血红蛋白浓度（Oxy-Hb）作为腹外侧PFC（VLPFC），背外侧PFC（DLPFC），和额极皮层（FPC）的皮质活动的指数，在14名受试者中进行了测量，而心率作为估计的运动强度在6名受试者。心理意象对前额叶氧合血红蛋白的影响也进行了探讨。在两侧，Oxy-Hb在VLPFC，DLPFC，和外侧FPC的正常速度行走开始前增加，而Oxy-Hb在内侧FPC行走开始前没有反应。在行走过程中，Oxy-Hb在双侧VLPFC中进一步增加，而在DLPFC和外侧和内侧FPC中降低。增加步行速度并没有改变VLPFC中Oxy-Hb的增加，但抵消了DLPFC中Oxy-Hb的减少（但不是在外侧和内侧FPC）。跑台运动诱发DLPFC中的Oxy-Hb增加更大（n = 5例受试者）。此外，在步行过程中增加认知需求，剥夺视觉反馈，抵消了减少Oxy-Hb在DLPFC和外侧和内侧FPC，但它不影响Oxy-Hb在VLPFC的增加。总之，深度和局部Oxy-Hb增加是VLPFC的独特反应。区域异质性的前额叶氧-血红蛋白的反应，自然地上步行加剧步行速度或认知需求的增加，这表明功能的PFC内的区别。
Using wireless multichannel near-infrared spectroscopy, regional difference in cortical activity over the prefrontal cortex (PFC) was examined before and during overground walking and in response to changes in speed and cognitive demand. Oxygenated hemoglobin concentration (Oxy-Hb) as index of cortical activity in ventrolateral PFC (VLPFC), dorsolateral PFC (DLPFC), and frontopolar cortex (FPC) was measured in 14 subjects, whereas heart rate was measured as estimation of exercise intensity in six subjects. The impact of mental imagery on prefrontal Oxy-Hb was also explored. On both sides, Oxy-Hb in VLPFC, DLPFC, and lateral FPC was increased before the onset of normal-speed walking, whereas Oxy-Hb in medial FPC did not respond before walking onset. During the walking, Oxy-Hb further increased in bilateral VLPFC, whereas Oxy-Hb was decreased in DLPFC and lateral and medial FPC. Increasing walking speed did not alter the increase in Oxy-Hb in VLPFC but counteracted the decrease in Oxy-Hb in DLPFC (but not in lateral and medial FPC). Treadmill running evoked a greater Oxy-Hb increase in DLPFC (n = 5 subjects). Furthermore, increasing cognitive demand during walking, by deprivation of visual feedback, counteracted the decrease in Oxy-Hb in DLPFC and lateral and medial FPC, but it did not affect the increase in Oxy-Hb in VLPFC. Taken together, the profound and localized Oxy-Hb increase is a unique response for the VLPFC. The regional heterogeneity of the prefrontal Oxy-Hb responses to natural overground walking was accentuated by increasing walking speed or cognitive demand, suggesting functional distinction within the PFC.