DNA repair and susceptibility to basal cell carcinoma: a case-control study.
DNA repair and susceptibility to basal cell carcinoma: a case-control study.
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DNA 修复和基底细胞癌易感性：病例对照研究。
DOI：
10.1093/oxfordjournals.aje.a117297
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发表时间：
1994
影响因子：
5
通讯作者：
Grossman,L
中科院分区：
文献类型：
--
作者：
Wei,Q;Matanoski,GM;Farmer,ER;Hedayati,MA;Grossman,L
本研究利用外周血淋巴细胞的宿主细胞再活化试验研究了DNA修复在日光诱导的基底细胞癌易感性中的作用。这项研究包括马里兰州基底细胞癌患者和无癌皮肤病对照者，他们在1987年至1990年间诊断出非癌性皮肤病。Logistic回归模型用于评估按DNA修复水平分层的选定变量的独立影响，并对年龄和家族史进行调整。皮肤类型、终生严重晒伤次数和光化性弹性组织变性也被选为基底细胞癌的危险因素。采用88例患者和135例对照的冻存淋巴细胞进行DNA修复试验。当数据按DNA修复水平分层，并根据年龄和皮肤癌家族史进行调整时，（比值比（OR）= 3.2，95%置信区间（Cl）1.5-7.3），一生中有六次或六次以上严重晒伤（OR = 4.2，95%CI 1.6-10.7）和中度或重度光化性弹性组织变性（OR = 4.4，95%CI 1.5-12.8），但在DNA修复水平较低的人群中未观察到。这些发现表明，受损的DNA修复可能是普通公众中日光诱导的皮肤癌的易感因素，就像着色性干皮病患者一样。
This study investigated the role of DNA repair in susceptibility to sunlight-induced basal cell carcinoma using a host cell reactivation assay in peripheral lymphocytes. The study included Maryland basal cell carcinoma patients and cancer-free derma tologic controls who had had noncancerous skin disorders diagnosed between 1987 and 1990. Logistic regression models were used to assess the independent effect of the selected variables stratified by DNA repair level, with adjustment for age and family history. Skin type, lifetime number of severe sunburns, and actinic elastosis were also selected as risk factors for basal cell carcinoma. Cryopreserved lymphocytes from 88 cases and 135 controls were used for the DNA repair assay. When data were stratified by DNA repair level and adjusted for age and family history of skin cancer, significantly increased odds ratios associated with lighter skin (odds ratio (OR) = 3.2, 95% confidence interval (Cl) 1.5–7.3), six or more severe sunburns in a lifetime (OR = 4.2, 95% Cl 1.6–10.7), and moderate or severe actinic elastosis (OR = 4.4, 95% Cl 1.5–12.8) were observed in persons with low DNA repair but not in those with high DNA repair. These findings suggest that impaired DNA repair may be a susceptibility factor for sunlight-induced skin cancer in the general public, as it is in patients with xeroderma pigmentosum.