Deciphering the BAR code of membrane modulators.
Deciphering the BAR code of membrane modulators.
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DOI：
10.1007/s00018-017-2478-0
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发表时间：
2017-07
期刊：
影响因子：
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通讯作者：
Djinović-Carugo K
中科院分区：
文献类型：
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作者：
Salzer U;Kostan J;Djinović-Carugo K
BAR结构域是“BAR结构域蛋白超家族”的表膜结构域，所述“BAR结构域蛋白超家族”是在膜细胞骨架界面起显著作用的大的且多样的多结构域蛋白的集合。BAR结构域同源二聚体是与脂质膜外周结合并参与膜雕刻活动的功能单元。它们的固有曲率和脂质结合特性的差异导致了膜调节特性的巨大变化。BAR结构域的膜活性通过分子内或亚基间结构域、分子间蛋白质相互作用和翻译后修饰进一步修饰和调节。而不是提供详细的细胞生物学信息，这个超家族的单个成员，这篇评论的重点是生物化学，生物物理学和结构方面和最近的研究结果，范式促进我们的理解过程驱动和调制BAR域。
The BAR domain is the eponymous domain of the “BAR-domain protein superfamily”, a large and diverse set of mostly multi-domain proteins that play eminent roles at the membrane cytoskeleton interface. BAR domain homodimers are the functional units that peripherally associate with lipid membranes and are involved in membrane sculpting activities. Differences in their intrinsic curvatures and lipid-binding properties account for a large variety in membrane modulating properties. Membrane activities of BAR domains are further modified and regulated by intramolecular or inter-subunit domains, by intermolecular protein interactions, and by posttranslational modifications. Rather than providing detailed cell biological information on single members of this superfamily, this review focuses on biochemical, biophysical, and structural aspects and on recent findings that paradigmatically promote our understanding of processes driven and modulated by BAR domains.