Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial
Quality of life at the end of primary treatment of breast cancer: First results from the moving beyond cancer randomized trial
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DOI：
10.1093/jnci/djh060
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发表时间：
2004-03-03
影响因子：
10.3
通讯作者：
Belin, TR
中科院分区：
文献类型：
--
作者：
Ganz, PA;Kwan, L;Belin, TR
背景：在过去的十年中，由于早期发现和辅助治疗的增加使用，乳腺癌的生存率有所提高。关于初级治疗结束和生存之间过渡期的心理社会方面的数据有限。我们调查了参加一项随机试验的女性的基线心理社会状态，该试验在主要治疗结束时测试了对女性的两种心理社会干预措施。方法：在手术（登记）后一个月内确定参与者，提供人口统计信息和有限的生活质量衡量标准。对他们进行跟踪直至完成主要治疗（入组），此时他们完成了邮寄的基线调查，其中包括生活质量的标准化测量（包括身体和情感功能的标准化量表）、情绪、症状和性功能。 1999年7月1日至2002年6月30日期间，共有558名患者（平均年龄= 56.9岁）参加了这项研究。根据接受的治疗检查健康结果：乳房切除术联合或不联合化疗，以及肿瘤切除术联合或不联合化疗。所有统计检验都是双面的。结果：在所有治疗组中，接受乳房切除术的患者在登记时身体机能最差（P
Background: During the last decade, survival rates for breast cancer have increased as a result of earlier detection and increased use of adjuvant therapy. Limited data exist on the psychosocial aspects of the transitional period between the end of primary treatment and survivorship. We investigated the baseline psychosocial status of women enrolled in a randomized trial testing two psychosocial interventions for women at the end of primary treatment. Methods: Participants, identified within I month after surgery (registration), provided demographic information and limited measures of quality of life. They were followed until they finished primary treatment (enrollment), at which time they completed a mailed baseline survey that included standardized measures of quality of life (including standardized scales of physical and emotional functioning), mood, symptoms, and sexual functioning. A total of 558 patients (mean age = 56.9 years) were enrolled in the study between July 1, 1999, and June 30, 2002. Health outcomes were examined according to treatment received: mastectomy with and without chemotherapy, and lumpectomy with and without chemotherapy. All statistical tests were two-sided. Results: Among all treatment groups, patients who had a mastectomy had the poorest physical functioning at registration (P