Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency
Platelets with 10% of the normal amount of glycoprotein VI have an impaired response to collagen that results in a mild bleeding tendency
复制标题
血小板%20with%2010%%20of%20the%20正常%20数量%20of%20糖蛋白%20VI%20有%20an%20受损%20反应%20到%20胶原%20that%20结果%20in%20a%20轻度%20出血%20倾向
DOI：
--
复制
发表时间：
1995
影响因子：
6.5
通讯作者：
K. Tanoue
中科院分区：
文献类型：
--
作者：
M. Arai;N. Yamamoto;M. Moroi;N. Akamatsu;K. Fukutake;K. Tanoue
血小板糖蛋白 VI (GPVI) 是一种 62kD 的膜蛋白，已被确定为胶原蛋白的血小板受体之一，因为 GPVI 缺陷的血小板表现出对胶原蛋白的异常反应和异常出血倾向。我们报道了一位有轻度出血史的女性患者，其血小板的 GPVI 表达量为正常血小板的 10%。患者血小板对 1-5 微克/毫升胶原蛋白的反应完全不存在形状变化、聚集和 ATP 释放，但对 ADP 和 Ca2+ 离子载体 A23187 的反应正常。尽管 GPVI 仅表达 10%，但患者血小板与包被胶原蛋白的粘附受到轻微影响（正常血小板的 40-60%）。流式细胞术研究表明，患者的血小板表达正常量的 GPIa/IIa 复合物。这些结果表明，与胶原诱导的形状变化和聚集相比，血小板 GPVI 对胶原的粘附作用较少。
Platelet glycoprotein VI (GPVI), a 62kD membrane protein, has been identified as one of the platelet receptors for collagen, since GPVI-deficient platelets exhibit abnormal responses to collagen and an abnormal bleeding tendency. We report a female patient with a mild bleeding history whose platelets expressed 10% GPVI of normal platelets. Shape change, aggregation and ATP release of the patient's platelets were completely absent in response to 1-5 micrograms/ml collagen but present normally in response to ADP and Ca2+ ionophore A23187. Adhesion of the patient's platelets to coated collagen was mildly affected (40-60% of normal platelets) in spite of only 10% expression of GPVI. Flow cytometrical studies revealed that the patient's platelets expressed normal amounts of the GPIa/IIa complex. These results suggest that platelet GPVI is less involved in adhesion to collagen than shape change and aggregation induced by collagen.
影响因子：
20.3
作者：
N. Tandon;C. Ockenhouse;N. Greco;G. Jamieson
通讯作者：
N. Tandon;C. Ockenhouse;N. Greco;G. Jamieson
与 VLA-2 相关的血小板表面胶原蛋白结合复合物的分离和表征。
DOI：
10.1016/s0006-291x(88)81211-7
发表时间：
1988
影响因子：
3.1
作者：
Santoro,SA;Rajpara,SM;Staatz,WD;WoodsJr,VL
通讯作者：
WoodsJr,VL