CORTICAL PROJECTIONS TO THE PARAMEDIAN TEGMENTAL AND BASILAR PONS IN THE MONKEY
CORTICAL PROJECTIONS TO THE PARAMEDIAN TEGMENTAL AND BASILAR PONS IN THE MONKEY
复制标题
DOI：
10.1002/cne.902280307
复制
发表时间：
1984-01-01
影响因子：
2.5
通讯作者：
SPENCER, RF
中科院分区：
文献类型：
--
作者：
LEICHNETZ, GR;SMITH, DJ;SPENCER, RF
用辣根过氧化物酶（HRP）逆行和顺行法研究了猴大脑皮质到旁正中被盖和基底脑桥的传出联系。6只卷尾猴（Cebus apella）接受跨环桥脑HRP凝胶植入物逆行标记皮质桥脑投射起源的细胞。另外4只卷尾猴、1只恒河猴（Macaca mulatta）和1只食蟹猴（Macaca fascicularis）在运动前区（6区）、额眼区（FEF，8区）、上级（5区）和下级（7区）顶叶小叶接受HRP凝胶植入，以正向标记皮质桥脑投射的过程和终止，并确认逆行研究。根据Mesulam（'78）的四甲基联苯胺方案处理脑并用暗视野显微镜进行研究。前运动区（6区）额叶皮层和FEF的皮质输入同侧旁正中基底脑桥的主要来源，而FEF，背侧前额叶凸面，背内侧前额叶（颗粒额叶协会）皮层的主要来源双边预测旁正中脑桥被盖。脑桥被盖网状核（NRTP）的内侧部分被认为是基底脑桥灰质的被盖延伸，其主要的皮质输入来自额叶。顶叶皮质向外侧NRTP和外侧基底脑桥投射。虽然存在的可能性，在NRTP的额叶和顶叶的眼场传出的会聚，FEF和前额叶皮质似乎是皮质投射到旁正中脑桥被盖，其中包含生理上定义的PPRF（旁正中脑桥网状结构），一个重要的preoculptum中心的主要来源。结果进行了讨论，在他们的潜在的皮质影响的oculerative系统。
The efferent connections of the cerebral cortex to paramedial tegmental and basilar pons were studied in the monkey by using the retrograde and orthograde capabilities of the horseradish peroxidase (HRP) technique. Six capuchin monkeys (Cebus apella) received transcannular pontine HRP gel implants to retrogradely label the cells of origin of corticopontine projections. Four additional capuchin monkeys, 1 rhesus (Macaca mulatta) and 1 cynomolgus (Macaca fascicularis) monkey received HRP gel implants in premotor (area 6), frontal eye field (FEF, area 8), superior (area 5) and inferior (area 7) parietal lobules to orthogradely label the course and termination of corticopontine projections and to confirm the retrograde studies. The brains were processed according to the tetramethylbenzidine protocol of Mesulam (''78) and studied with darkfield microscopy. Premotor (area 6) frontal cortex and FEF were the main sources of cortical inputs to the ipsilateral paramedian basilar pons, whereas FEF, dorsal prefrontal convexity, and dorsal medial prefrontal (granular frontal association) cortex were the main sources of bilateral projections to the paramedian pontine tegmentum. The medial portion of the nucleus reticularis tegmenti pontis (NRTP), considered to be a tegmental extension of the basilar pontine gray, received its principal cortical input from the frontal lobe. Parietal cortex was observed to project to lateral NRTP and lateral basilar pons. Although the possibility exists of convergence of frontal and parietal eye field efferents in the NRTP, the FEF and prefrontal cortex appear to be the principal source of cortical projections to the paramedian pontine tegmentum, which contains the physiologically defined PPRF (paramedian pontine reticular formation), an important preoculomotor center. The results are discussed in terms of their potential cortical influence on the oculomotor system.