Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma
Serum vitamin D levels and exercise-induced bronchoconstriction in children with asthma
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DOI：
10.1183/09031936.00044710
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发表时间：
2011-06-01
影响因子：
24.3
通讯作者：
Boner, A. L.
中科院分区：
文献类型：
--
作者：
Chinellato, I.;Piazza, M.;Boner, A. L.
流行病学研究已经确定了健康成人血清维生素D水平低和肺功能下降与儿童哮喘发作和严重程度之间的关系。然而，没有研究探讨维生素D水平与哮喘儿童运动诱发支气管收缩之间的关系。我们评估了25-羟基维生素D浓度与基线用力肺活量（FVC）之间的关系，1秒用力呼气量（FEV 1）和FEV 1的变化在45名间歇性哮喘儿童中，只有11%的儿童血清维生素D水平达到理想水平（至少30-40 ng.mL（-1））。血清25-羟维生素D与FVC（r=0.34; p=0.037）和FEV 1（r=0.32; p=0.037）呈正相关。对运动挑战有积极反应的受试者（Δ FEV 1>= 10%）的儿童血清25-羟基维生素D水平低于阴性激发的儿童。（平均值+/- SD分别为16.2 +/- 5.2 vs 23.4 +/- 7.0 ng.mL（-1）;我们的研究结果表明，维生素D缺乏症是常见的哮喘儿童谁住在地中海国家。在这些儿童中，维生素D水平较低与肺功能降低和对运动的反应性增加有关。
Epidemiological studies have established a relationship between low levels of serum vitamin D and reduced lung function in healthy adults, and asthma onset and severity in children. However, no study has examined the relationship between vitamin D levels and exercise-induced bronchoconstriction in asthmatic children.We evaluated the relationship between 25-hydroxyvitamin D concentrations and baseline forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and change in FEV1 (Delta FEV1) after a standardised exercise challenge in 45 children with intermittent asthma.Only 11% of the children had desirable serum vitamin D levels (at least 30-40 ng.mL(-1)). A positive correlation was found between serum 25-hydroxyvitamin D and both FVC (r=0.34; p=0.037) and FEV1 (r=0.32; p=0.037). Subjects with a positive response to the exercise challenge (Delta FEV1 >= 10%) presented lower serum levels of 25-hydroxyvitamin D than children with a negative challenge (mean +/- SD 16.2 +/- 5.2 versus 23.4 +/- 7.0 ng.mL(-1), respectively; p=0.001).Our results indicate that hypovitaminosis D is frequent in asthmatic children who live in a Mediterranean country. In those children, lower levels of vitamin D are associated with reduced lung function and increased reactivity to exercise.