Laser Assisted Drug Delivery: A Review of An Evolving Technology
Laser Assisted Drug Delivery: A Review of An Evolving Technology
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DOI：
10.1002/lsm.22227
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发表时间：
2014-04-01
影响因子：
2.4
通讯作者：
Ozog, David M.
中科院分区：
文献类型：
--
作者：
Sklar, Lindsay R.;Burnett, Christopher T.;Ozog, David M.
背景：外用药物的皮肤生物利用度相对较低。目的：本文综述了激光辅助给药的现有应用，通过激光辅助给药可以促进外用药物对皮肤的渗透。结果：现有文献表明，激光是一种安全有效的促进外用药物经皮给药的方法。在药物输送方面，最常被研究的激光类型是二氧化碳(CO2)和铒：钇-铝-石榴石(Er：YAG)激光器。限制：现有的激光辅助给药研究大多是在动物模型上进行的，还需要进行更多的人体实验。结论：激光辅助给药是一种发展中的技术，具有广阔的临床应用前景。多项研究表明，激光对皮肤的预处理可以增加局部皮肤和全身应用药物分子的渗透性和渗透深度。激光外科医生。2014年，46：249-262。(C)2014年威利期刊公司。
Background: Topically applied drugs have a relatively low cutaneous bioavailability.Objective: This article reviews the existing applications of laser assisted drug delivery, a means by which the permeation of topically applied agents can be enhanced into the skin.Results: The existing literature suggests that lasers are a safe and effective means of enhancing the delivery of topically applied agents through the skin. The types of lasers most commonly studied in regards to drug delivery are the carbon dioxide (CO2) and erbium:yttrium-aluminum-garnet (Er:YAG) lasers. Both conventional ablative and fractional ablative modalities have been utilized and are summarized herein.Limitations: The majority of the existing studies on laser assisted drug delivery have been performed on animal models and additional human studies are needed.Conclusions: Laser assisted drug delivery is an evolving technology with potentially broad clinical applications. Multiple studies demonstrate that laser pretreatment of the skin can increase the permeability and depth of penetration of topically applied drug molecules for both local cutaneous and systemic applications. Lasers Surg. Med. 46:249-262, 2014. (C) 2014 Wiley Periodicals, Inc.