Acute treatments with GMP produce antidepressant-like effects in mice
Acute treatments with GMP produce antidepressant-like effects in mice
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DOI：
10.1097/00001756-200006260-00008
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发表时间：
2000-06-26
期刊：
影响因子：
1.7
通讯作者：
Rodrigues, ALS
中科院分区：
文献类型：
--
作者：
Eckeli, AL;Dach, F;Rodrigues, ALS
这项研究检验了 GMP 对两种小鼠抑郁模型的影响。 GMP（剂量范围：分别为 5-50 mg/kg 和 5-100 mg/kg，腹膜内注射）显着减少了强迫游泳试验 (FST) 和悬尾试验 (TST) 中的不动时间，而旷场中的行走没有伴随变化。 I.c.v.注射 GMP（320-480 nmol/位点）也减少了 FST 中的不动性，但不影响行走。用MK-801（0.01 mg/kg）+ GMP（50 mg/kg）治疗的小鼠的不动性与单独用MK-801或GMP获得的结果没有显着差异，但GMP（或MK-801）+丙咪嗪（15 mg/kg）治疗诱导的FST效果比单独施用任一药物更强。用对氯苯丙氨酸（100 mg/kg，4 天）预处理完全阻断了 GMP、MK-801 或氟西汀（32 mg/kg）的抗不动作用，但仅部分阻断了 FST 中丙咪嗪的抗不动作用。结果表明，服用 GMP（如 MK-801）产生的抗抑郁样作用可能是由于 NMDA 受体阻断导致的间接血清素激活所致。 NeuroReport 11：[839-1843 (C) 2000 Lippincott Williams & Wilkins。
This study examined the effect of GMP in two models of depression in mice. The immobility times in the forced swimming test (FST) and in the tail suspension test (TST) were significantly reduced by GMP (dose range: 5-50 mg/kg and 5-100 mg/kg, i.p., respectively), without accompanying changes in ambulation in an open-field. I.c.v. injection of GMP (320-480 nmol/site) also reduced the immobility in the FST without affecting ambulation. The immobility of mice treated with MK-801 (0.01 mg/kg) + GMP (50 mg/kg) was not significantly different from the result obtained with MK-801 or GMP alone, but GMP (or MK-801) + imipramine (15 mg/kg) treatment induced a stronger effect in FST than administration of either drug alone. Pretreatment with p-chlorophenylalanine (100 mg/kg, 4 days) completely blocked the anti-immobility effect of GMP, MK-801 or fluoxetine (32 mg/kg), but only partially that of imipramine in the FST. The results suggest that the antidepressant-like effects produced by the administration of GMP, like MK-801, may be due to an indirect serotonin activation resulting from blockade of NMDA receptors. NeuroReport 11:[839-1843 (C) 2000 Lippincott Williams & Wilkins.