A novel noninvasive videographic method for quantifying changes in the chromaticity of the optic nerve head with changes in the intraocular pressure, pulsatile choroidal blood flow and visual neural function in humans.
A novel noninvasive videographic method for quantifying changes in the chromaticity of the optic nerve head with changes in the intraocular pressure, pulsatile choroidal blood flow and visual neural function in humans.
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DOI：
10.1016/0039-6257(94)90045-0
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发表时间：
1994-05-01
影响因子：
5.1
通讯作者：
Kergoat, H
中科院分区：
文献类型：
--
作者：
Lovasik, J V;Gagnon, M;Kergoat, H
青光眼中的视力丧失可能是由于眼内压（IOP）对神经节细胞轴突的压缩作用、至视神经的血流受损或这两个因素的某种组合。虽然降低IOP可以保护IOP升高患者的视力，但并非所有患者都能从这种治疗方法中获得长期益处。神经节细胞的存活可能更依赖于视神经乳头（ONH）的血管灌注程度。在这份报告中，我们提出了一些初步的数据，一种新的非侵入性的视频技术，详细说明的能力，ONH血管系统，以维持灌注恒定的存在下，短暂的眼压升高和降低眼灌注压（IOP）。视觉正常受试者（n = 5）测试眼中ONH的短期逐步减少系统地改变了ONH的色度（色调、饱和度、亮度）和脉络膜中的脉动眼血流（POBF）。在视觉正常受试者（n = 7）中，双侧图形反转视网膜电图（pERG）的显著衰减表明，视网膜电图的类似短暂降低损害了正常的视网膜生理学。该技术还用于揭示与心脏脉搏率相关的ONH色度的自发节律变化。这种所谓的“彩色脉搏”的ONH提供了一个潜在的有用的临床指标，评价血管灌注的ONH。动态数字成像检测异常血流动力学在ONH的诊断和预后的潜力进行了讨论。
Vision loss in glaucoma may be due to the compressive effects of the intraocular pressure (IOP) on the ganglion cell axons, impaired blood flow to the optic nerve, or some combination of these two factors. While reducing the IOP may preserve vision in patients with elevated IOP, not all patients experience longterm benefits from this therapeutic approach. The survival of ganglion cells may be more dependent upon the degree of vascular perfusion of the optic nerve head (ONH). In this report we present some preliminary data on a new noninvasive videographic technique for elaborating the capacity of the ONH vasculature to maintain perfusion constancy in the presence of transient elevations of the IOP and reductions of the ocular perfusion pressure (OPP). Shortterm, stepwise reductions of the OPP in the test eye of visually normal subjects (n = 5) systematically altered both the chromaticity (hue, saturation, brightness) of the ONH and the pulsatile ocular blood flow (POBF) in the choroid. Similar transient reductions in the OPP were seen to impair normal retinal physiology, as indicated by a significant attenuation of the bilateral pattern-reversal electroretinograms (pERGs) in visually normal subjects (n = 7). This technique was also used to reveal spontaneous rhythmical variations in the ONH chromaticity which were linked to the cardiac pulse rate. This so-called "chromatic pulse" of the ONH offers potential as a useful clinical index for evaluating the vascular perfusion of the ONH. The diagnostic and prognostic potential of dynamic digital imaging for the detection of abnormal hemodynamics in the ONH is discussed.