PBCA-based polymeric microbubbles for molecular imaging and drug delivery
PBCA-based polymeric microbubbles for molecular imaging and drug delivery
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DOI：
10.1016/j.jconrel.2017.03.006
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发表时间：
2017-08-10
影响因子：
10.8
通讯作者：
Lammers, Twan
中科院分区：
文献类型：
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作者：
Koczera, Patrick;Appold, Lia;Lammers, Twan
微泡 (MB) 通常用作超声 (US) 成像的造影剂。我们描述了不同类型的靶向载药聚（氰基丙烯酸正丁酯）（PBCA）MB，并证明了它们对多种生物医学应用的适用性，包括分子超声成像和超声介导的药物输送。通过用识别 E-选择素和 VCAM-1 的肽和抗体修饰 PBCA MB 的表面，可以对血管生成肿瘤血管和发炎的动脉粥样硬化内皮进行分子成像。 PBCA MB 的稳定惯性空化能够对肿瘤和大脑中的血管进行声孔和透化，可用于直接和间接药物输送。直接药物递送基于超声诱导的（模型）药物分子从 MB 壳中的释放。间接药物递送是指US和MB介导的共同给药药物和药物递送系统的外渗和渗透的增强。这些发现与最近报道的开创性原理验证研究相一致，该研究表明（磷脂）MB 在分子超声成像和声孔增强患者药物输送方面的有用性。他们的目的是举例说明将 MB 与 US 相结合以改善疾病诊断和治疗的潜力和广泛适用性。 (C) 2017 Elsevier B.V. 保留所有权利。
Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. We describe different types of targeted and drug-loaded poly(n-butyl cyanoacrylate) (PBCA) MB, and demonstrate their suitability for multiple biomedical applications, including molecular US imaging and US-mediated drug delivery. Molecular imaging of angiogenic tumor blood vessels and inflamed atherosclerotic endothelium is performed by modifying the surface of PBCA MB with peptides and antibodies recognizing E-selectin and VCAM-1. Stable and inertial cavitation of PBCA MB enables sonoporation and permeabilization of blood vessels in tumors and in the brain, which can be employed for direct and indirect drug delivery. Direct drug delivery is based on US-induced release of (model) drug molecules from the MB shell. Indirect drug delivery refers to US-and MB-mediated enhancement of extravasation and penetration of co-administered drugs and drug delivery systems. These findings are in line with recently reported pioneering proof-of-principle studies showing the usefulness of (phospholipid) MB for molecular US imaging and sonoporation-enhanced drug delivery in patients. They aim to exemplify the potential and the broad applicability of combining MB with US to improve disease diagnosis and therapy. (C) 2017 Elsevier B.V. All rights reserved.