Synergistic mixture interactions in detection of perithreshold odors by humans
Synergistic mixture interactions in detection of perithreshold odors by humans
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DOI：
10.1093/chemse/bjn004
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发表时间：
2008-04-01
期刊：
影响因子：
3.5
通讯作者：
Wise, Paul M.
中科院分区：
文献类型：
--
作者：
Miyazawa, Toshio;Gallagher, Michelle;Wise, Paul M.
人类气味感知中协同混合物相互作用的实验室演示很少见。当前的研究检查了枫内酯 (ML) 和选定的羧酸之间的阈值混合物相互作用。空气稀释嗅觉计可以实现精确的刺激控制。实验人员结合固相微萃取和气相色谱/质谱法测量了气相中的刺激物浓度。测量纯机器学习的检测概率与浓度或心理测量函数的关系。通过添加固定的、低于阈值浓度的羧酸，还测量了 ML 的心理测量功能。相对于检测中的统计独立性，在一系列 ML 浓度范围内出现了明显的协同作用。据我们所知，目前的结果首次清楚地证明了人类在气味检测方面的协同作用，该实验结合了精确的刺激控制、刺激的气相校准和协同作用的明确统计定义。
Laboratory demonstrations of synergistic mixture interactions in human odor perception have been rare. The current study examined perithreshold mixture interactions between maple lactone (ML) and selected carboxylic acids. An air-dilution olfactometer allowed precise stimulus control. Experimenters measured stimulus concentrations in vapor phase using a combination of solid-phase microextraction and gas chromatography/mass spectrometry. A probability of detection versus concentration, or a psychometric, functions was measured for pure ML. Psychometric functions were also measured for ML with the addition of fixed, subthreshold concentrations of carboxylic acids. Relative to statistical independence in detection, clear synergy occurred over a range of ML concentrations. To the best of our knowledge, the current results constitute the first clear demonstration of synergy in odor detection by humans from an experiment that combined precise stimulus control, vapor-phase calibration of stimuli, and a clear statistical definition of synergy.