Time trends in the incidence, prevalence and age at diagnosis of asthma in children
Time trends in the incidence, prevalence and age at diagnosis of asthma in children
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DOI：
10.1111/pai.12376
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发表时间：
2015-06-01
影响因子：
4.4
通讯作者：
Verhamme, Katia M. C.
中科院分区：
文献类型：
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作者：
Engelkes, Marjolein;Janssens, Hettie M.;Verhamme, Katia M. C.
背景目前对哮喘患病率的认识主要基于横断面问卷调查数据。目前基于人群的儿童哮喘发病率的数据是稀缺的。Objectives研究的发病率，患病率和年龄在诊断哮喘的儿童在荷兰在研究期间2000-2012.MethodsA人群为基础的队列研究进行了综合初级保健信息数据库。该队列包括176，516名儿童（随访379，536人年（PY）），年龄在2000年至2012年之间，5- 18岁。所有经医生诊断为哮喘的儿童的医疗记录均经过验证。计算哮喘的发病率、年变化百分比（APC）和患病率。年龄和性别对发病率的影响和诊断时年龄的变化进行了study.ResultsWe确定了一个哮喘队列的14,303名儿童与35,118 PY。总体发生率为6.7/1000 PY（95% CI，6.45-6.97）。直到2008年，发病率显著增加（APC 5.79（95% CI 1.43-10.34））;从2008年起，观察到非显著下降（APC -12.16（95% CI -23.07至0.28）。女孩的发病率低于男孩，这种差异随着年龄的增长而减小。（p
BackgroundCurrent knowledge on the prevalence of asthma is mainly based on cross-sectional questionnaire data. Current population-based data on the incidence of asthma in children are scarce.ObjectiveTo study the incidence, prevalence, and age at diagnosis of asthma in children in the Netherlands over the study period 2000-2012.MethodsA population-based cohort study was conducted in the Integrated Primary Care Information database. The cohort consisted of 176,516 children (379,536 personyears (PY) of follow-up), aged 5-18years between 2000 and 2012. All medical records of children with physician diagnosed asthma were validated. Incidence rates, annual percent change (APC), and prevalence for asthma were calculated. Influence of age and gender on incidence rates and change in age at diagnosis were studied.ResultsWe identified an asthma cohort of 14,303 children with 35,118 PY. The overall incidence rate was 6.7/1000 PY (95% CI, 6.45-6.97). Until 2008, the incidence rate was significantly increasing (APC 5.79 (95% CI 1.43-10.34); from 2008 onwards, a non-significant decrease was observed (APC -12.16 (95% CI -23.07 to 0.28). Incidence for girls was lower than for boys, this difference decreased with increasing age. (p