The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics.
The Unfolded Protein Response: At the Intersection between Endoplasmic Reticulum Function and Mitochondrial Bioenergetics.
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DOI：
10.3389/fonc.2017.00055
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发表时间：
2017
影响因子：
4.7
通讯作者：
Hetz C
中科院分区：
文献类型：
--
作者：
Carreras-Sureda A;Pihán P;Hetz C
内质网(ER)与线粒体的通讯是近年来出现的一种调节细胞生理的信号中枢，在癌症和神经变性等疾病中起着重要作用。这种功能整合是通过被称为线粒体相关膜(MAM)的离散细胞器间结构来实现的。在这些区域，内质网/线粒体在物理上相互联系，动态调整代谢需求和对应激刺激的反应。在这里，我们提供了内质网如何塑造线粒体功能的重点概述，特别强调了MAM中未折叠蛋白反应的局部信号传递的重要性。对细胞命运控制和癌症进展的意义也进行了讨论。
Endoplasmic reticulum (ER) to mitochondria communication has emerged in recent years as a signaling hub regulating cellular physiology with a relevant contribution to diseases including cancer and neurodegeneration. This functional integration is exerted through discrete interorganelle structures known as mitochondria-associated membranes (MAMs). At these domains, ER/mitochondria physically associate to dynamically adjust metabolic demands and the response to stress stimuli. Here, we provide a focused overview of how the ER shapes the function of the mitochondria, giving a special emphasis to the significance of local signaling of the unfolded protein response at MAMs. The implications to cell fate control and the progression of cancer are also discussed.