Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature.
Concurrent fNIRS and fMRI processing allows independent visualization of the propagation of pressure waves and bulk blood flow in the cerebral vasculature.
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DOI：
10.1016/j.neuroimage.2012.03.009
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发表时间：
2012-07-16
期刊：
影响因子：
5.7
通讯作者：
Frederick, Blaise deB.
中科院分区：
文献类型：
--
作者：
Tong, Yunjie;Frederick, Blaise deB.
关键词：
血氧水平依赖（BOLD）功能磁共振成像（fMRI）的血氧变化，这是受生理过程的影响，包括心脏搏动，呼吸，和低频振荡（LFO）。识别这些过程对BOLD信号的时空影响具有挑战性，因为BOLD的低采样率会导致高频生理信号成分的混叠。在这项研究中，我们在静息状态下对6名受试者进行了并发功能近红外光谱（fNIRS）和功能磁共振成像（fMRI）扫描。为了减少混叠，在一组顺序获取的切片堆栈上重复进行BOLD fMRI采集，将TR降低到0.5秒，同时保持高空间分辨率。采用渐进式时间延迟回归插值（RIPTiDe）方法，将fNIRS（无混叠）获取的生理信号及其时间位移作为fMRI分析中的回归量，以确定各种生理过程对BOLD信号影响的幅度和时间。心脏搏动波通过的时间和脑血本身的时间的细节都被绘制出来了。结果表明，心脏信号对大血管（动脉和静脉）附近体素的影响最大，而LFO对引流静脉的影响最大。我们假设这可能是脑血径长度和信号传播动力学差异的结果。总之，这些结果验证并扩展了一种新的成像技术，可以动态跟踪脉冲波和大量血流，同时使用fMRI和fNIRS。
Blood Oxygen Level Dependent (BOLD) functional magnetic resonance imaging (fMRI) changes in blood oxygenation, which is affected by physiological processes, including cardiac pulsation, breathing, and low frequency oscillations (LFO). It is challenging to identify spatial and temporal effects of these processes on the BOLD signal because the low sampling rate of BOLD leads to aliasing of higher frequency physiological signal components. In this study, we used concurrent functional near infrared spectroscopy (fNIRS) and fMRI on 6 subjects during a resting state scan. To reduce aliasing, the BOLD fMRI acquisition was repeatedly performed on a set of sequentially acquired slice stacks to lower the TR to 0.5 sec while retaining high spatial resolution. Regressor interpolation at progressive time delays (RIPTiDe) method was used, in which physiological signal acquired by fNIRS (without aliasing) and its temporal shifts were used as regressors in the fMRI analysis to determine the magnitude and timing of the effects of various physiological processes on the BOLD signal. The details of the timing of the passage of the cardiac pulsation wave and of the cerebral blood itself were mapped. The result suggests that the cardiac signal affects the voxels near large blood vessels (arteries and veins) most strongly, while LFO mostly affected the drainage veins. We hypothesize this could be the result of differences in the cerebral blood path lengths, and differences in the dynamics of the propagation of the signals. Together these results validate and extend a novel imaging technique to dynamically track the pulse-wave and bulk blood flow with concurrent fMRI and fNIRS.
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影响因子：
3.5
作者：
Tong, Yunjie;Hocke, Lia Maria;Frederick, Blaise deB
通讯作者：
Frederick, Blaise deB
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