Transcriptional profiling of differentially expressed long non-coding RNAs in breast cancer.
Transcriptional profiling of differentially expressed long non-coding RNAs in breast cancer.
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乳腺癌中差异表达的长非编码RNA的转录谱
DOI：
10.1016/j.gdata.2015.09.020
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Cao F
中科院分区：
文献类型：
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作者：
Wang L;Shen X;Xie B;Ma Z;Chen X;Cao F
长链非编码RNA（longnon-codingRNA，lncRNA）是一类在肿瘤生物学中起重要作用的非编码RNA。然而，关于它们在乳腺癌发病机制中的机制作用知之甚少，特别是在具有特别差的结果的三阴性乳腺癌（TNBC）中。本研究专门设计用于鉴定乳腺癌中与lncRNA相关的特征并表征调节表型的lncRNA。在这里，我们提供了详细的方法和分析的微阵列数据，这是存放在基因表达综合（GEO）与登录号GSE 64790。在Oncotarget上发表的手稿（PMID 26078338）中包含的基本分析。这些数据可用于进一步阐明乳腺癌的发病机制。
Long non-coding RNAs (lncRNAs) are subclass of noncoding RNAs that have been recently shown to play critical roles in cancer biology. However, little is known about their mechanistic role in breast cancer pathogenesis, especially in triple-negative breast carcinomas (TNBC) that have particular poor outcomes. This study was specifically designed to identify the signatures relevant lncRNAs in breast cancer and characterize lncRNAs that modulate the phenotype. Here we provide detailed methods and analysis of microarray data, which is deposited in the Gene Expression Omnibus (GEO) with the accession number GSE64790. The basic analysis as contained in the manuscript published in Oncotarget with the PMID 26078338. These data can be used to further elucidate the mechanisms of breast cancer.