ANTIMICROBIAL THERAPY OF EXPERIMENTAL ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS-AUREUS
ANTIMICROBIAL THERAPY OF EXPERIMENTAL ENDOCARDITIS CAUSED BY STAPHYLOCOCCUS-AUREUS
复制标题
DOI：
10.1093/infdis/131.4.367
复制
发表时间：
1975-01-01
影响因子：
6.4
通讯作者：
JOHNSON, ML
中科院分区：
文献类型：
--
作者：
SANDE, MA;JOHNSON, ML
在兔心内膜炎模型上，研究了不同抗菌剂对心脏赘生物中金黄色葡萄球菌的清除率。各种药物和组合对肉汤中高滴度细菌的杀灭率与这些药物在体内的相对有效性有关。庆大霉素和青霉素在体外具有协同作用，在体内对心脏赘生物的杀菌效果比单独使用青霉素更有效。万古霉素对细菌的杀灭率与青霉素和庆大霉素合用的杀灭率相似，头孢唑林的杀灭率与青霉素单独使用时相似。在体内和体外，克林霉素的效果都不如青霉素。利福平治疗导致了耐药生物的出现，当与青霉素联合使用时，这种药物在体外和体内的效果都不如单独使用青霉素。该模型为葡萄球菌性心内膜炎的抗菌治疗提供了一种有效的评价方法。
The rate at which various antimicrobial agents eradicatedStaphylococcus aureusfrom cardiac vegetations in a rabbit model of endocarditis was studied. The rate at which various drugs and combinations killed high titers of bacteria in broth correlated with the relative effectiveness of the agents in vivo. Gentamicin plus penicillin proved to be synergistic in vitro and more effective in eradicating bacteria from cardiac vegetations in vivo than was penicillin alone. Vancomycin killed bacteria at a rate similar to that for the combination of penicillin and gentamicin, and the rate for cefazolin was similar to that for penicillin alone. Clindamycin was less effective in vivo and in vitro than penicillin. Therapy with rifampin led to the emergence of resistant organisms, and, when combined with penicillin, this drug was less effective in vitro and in vivo than was penicillin alone. This model appears to offer an effective method for evaluation of antimicrobial treatment of staphylococcal endocarditis.