A Comprehensive Wiring Diagram of the Protocerebral Bridge for Visual Information Processing in the Drosophila Brain
A Comprehensive Wiring Diagram of the Protocerebral Bridge for Visual Information Processing in the Drosophila Brain
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DOI：
10.1016/j.celrep.2013.04.022
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发表时间：
2013-05-01
期刊：
影响因子：
8.8
通讯作者：
Chiang, Ann-Shyn
中科院分区：
文献类型：
--
作者：
Lin, Chih-Yung;Chuang, Chao-Chun;Chiang, Ann-Shyn
大脑如何感知感官信息并产生有意义的行为，关键取决于其底层电路。前脑桥（PB）是昆虫中央复合体（CX）的重要组成部分，CX是一个类似于人类基底神经节的前运动中心。在这里，通过解构数百个PB单神经元并将它们重建到一个通用的三维框架中，我们构建了一个具有标记极性和预测信息流方向的PB回路的全面地图。我们的分析揭示了一个高度有序的信息处理系统，涉及通过194个不同的PB神经元类型的CX亚基之间的定向信息流。电路特性，如镜像，收敛，发散，平铺，混响，和平行信号传播进行了观察，其功能和进化的意义进行了讨论。PB神经元回路的这种布局可以为进一步研究感觉（例如，视觉）输入到苍蝇大脑中的运动命令中。
How the brain perceives sensory information and generates meaningful behavior depends critically on its underlying circuitry. The protocerebral bridge (PB) is a major part of the insect central complex (CX), a premotor center that may be analogous to the human basal ganglia. Here, by deconstructing hundreds of PB single neurons and reconstructing them into a common three-dimensional framework, we have constructed a comprehensive map of PB circuits with labeled polarity and predicted directions of information flow. Our analysis reveals a highly ordered information processing system that involves directed information flow among CX subunits through 194 distinct PB neuron types. Circuitry properties such as mirroring, convergence, divergence, tiling, reverberation, and parallel signal propagation were observed; their functional and evolutional significance is discussed. This layout of PB neuronal circuitry may provide guidelines for further investigations on transformation of sensory (e.g., visual) input into locomotor commands in fly brains.