Supramolecular Chemistry of Carbohydrate Clusters with Cores Having Guest Binding Abilities
Supramolecular Chemistry of Carbohydrate Clusters with Cores Having Guest Binding Abilities
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DOI：
10.1002/chin.200813271
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发表时间：
2007-01
期刊：
影响因子：
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通讯作者：
A. Vargas-Berenguel;F. Ortega-Caballero;J. Casas-Solvas
中科院分区：
文献类型：
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作者：
A. Vargas-Berenguel;F. Ortega-Caballero;J. Casas-Solvas
本综述重点关注基于环糊精核心的碳水化合物簇的蛋白质受体和客体结合能力。两种络合能力的结合是开发位点特异性药物递送系统所追求的方法之一的基础。讨论了附加糖的数量、碳水化合物簇的类型和间隔臂的类型等因素对分子识别特性的影响。
This review concentrates on both the protein receptor and guest binding abilities of carbohydrate clusters based on a cyclodextrin core. The combination of both complexation abilities is the basis of one of the pursued approaches for developing site-specific drug delivery systems. Influence on the molecular recognition properties of the number of appended saccharides, the type of carbohydrate clustering and the type of the spacer arms, among other factors, are discussed.