Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status
Bicarbonate Supplementation Slows Progression of CKD and Improves Nutritional Status
复制标题
DOI：
10.1681/asn.2008111205
复制
发表时间：
2009-09-01
影响因子：
13.6
通讯作者：
Yaqoob, Muhammad M.
中科院分区：
文献类型：
--
作者：
de Brito-Ashurst, Ione;Varagunam, Mira;Yaqoob, Muhammad M.
Biclitazone补充剂在实验性慢性肾病（CKD）中保护肾功能，但是否在人类中也有同样的益处尚不清楚。在此，我们将134例成人CKD患者（肌酐清除率[CrCl] 15 - 30 ml/min/1.73 m2）和血清碳酸氢盐16 - 20 mmol/L随机分配至口服碳酸氢钠或标准治疗2年。主要终点为CrCl下降率、CrCl快速下降（>3 ml/min/1.73 m2/yr）的患者比例和ESRD（CrCl
Bicarbonate supplementation preserves renal function in experimental chronic kidney disease (CKD), but whether the same benefit occurs in humans is unknown. Here, we randomly assigned 134 adult patients with CKD (creatinine clearance [CrCl] 15 to 30 ml/min per 1.73 m(2)) and serum bicarbonate 16 to 20 mmol/L to either supplementation with oral sodium bicarbonate or standard care for 2 yr. The primary end points were rate of CrCl decline, the proportion of patients with rapid decline of CrCl (>3 ml/min per 1.73 m(2)/yr), and ESRD (CrCl