Bacterial Cell-Cell Communication in the Host via RRNPP Peptide-Binding Regulators.
Bacterial Cell-Cell Communication in the Host via RRNPP Peptide-Binding Regulators.
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DOI：
10.3389/fmicb.2016.00706
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发表时间：
2016
影响因子：
5.2
通讯作者：
Gardan R
中科院分区：
文献类型：
--
作者：
Perez-Pascual D;Monnet V;Gardan R
人类微生物群是由复杂而密集的细菌联合体组成的。在这些环境中，细菌能够通过小信号分子在群体水平上协调它们的基因表达，从而对变化做出快速反应。在革兰氏阳性菌中，细胞间的通讯主要由释放到细胞外环境的肽介导。基于这些肽的细胞间通讯在厚壁菌门中尤其普遍，它们调节一系列生物过程，包括与宿主-微生物相互作用相关的功能。在不同的通讯媒介中，胞质转录调节因子RRNPP家族及其同源的再内化信号肽代表了一组新兴的重要性。目前研究的RRNPP成员主要存在于杆菌、链球菌和肠球菌中。这些细菌的特点是人类共生和致病，并与其他微生物在人体内共享不同的生态位。这篇小型综述的目的是介绍宿主背景下RRNPP机制生物学相关性的研究现状，强调它们在共生或毒力中的特定作用。
Human microbiomes are composed of complex and dense bacterial consortia. In these environments, bacteria are able to react quickly to change by coordinating their gene expression at the population level via small signaling molecules. In Gram-positive bacteria, cell–cell communication is mostly mediated by peptides that are released into the extracellular environment. Cell–cell communication based on these peptides is especially widespread in the group Firmicutes, in which they regulate a wide array of biological processes, including functions related to host–microbe interactions. Among the different agents of communication, the RRNPP family of cytoplasmic transcriptional regulators, together with their cognate re-internalized signaling peptides, represents a group of emerging importance. RRNPP members that have been studied so far are found mainly in species of bacilli, streptococci, and enterococci. These bacteria are characterized as both human commensal and pathogenic, and share different niches in the human body with other microorganisms. The goal of this mini-review is to present the current state of research on the biological relevance of RRNPP mechanisms in the context of the host, highlighting their specific roles in commensalism or virulence.