Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: Initial experience
Detection of primary breast carcinoma with a dedicated, large-field-of-view FDG PET mammography device: Initial experience
复制标题
DOI：
10.1148/radiol.2342040654
复制
发表时间：
2005-02-01
期刊：
影响因子：
19.7
通讯作者：
Coleman, RE
中科院分区：
文献类型：
--
作者：
Rosen, EL;Turkington, TG;Coleman, RE
目得：为了前瞻性地评估一个专用的，大视野的正电子发射断层扫描（PET）乳腺摄影设备成像原发性breast carcinoma.MATERIALS AND METHODS：机构审查委员会批准获得本研究，所有患者提供书面知情同意书之前参与。受试者从诊断性乳腺X线摄影和/或超声检查显示病变高度提示恶性肿瘤的患者队列中招募。23名符合入选标准的患者随后使用与托马斯杰斐逊国家加速器设施（纽波特纽斯，弗吉尼亚州）联合开发的专用PET乳腺X射线摄影装置进行成像。给予2.0-2.5 mCi（74.0-93.5 MBq）氟脱氧葡萄糖后1小时，对受累乳房进行5分钟PET乳房X线摄影。图像处理和重建的横向头尾和冠状面。对于每个病变，在PET乳腺X线摄影后立即进行图像引导的粗针活检。常规乳腺X线摄影结果和组织学检查结果与PET乳腺X线摄影图像相关。PET乳腺摄影显示恶性病变的敏感性，特异性，阴性预测值，阳性预测值进行了计算。结果：PET乳腺摄影显示20个局灶性异常，其中18个是恶性的，两个是良性的。这两个良性病变代表脂肪坏死区域。20例恶性病变中有3例在常规乳腺X线摄影中显示，但在PET乳腺X线摄影中未显示。PET乳腺摄影对恶性肿瘤的总体敏感性为86%（95%置信区间：65%，95%），阳性预测值为90%（95%置信区间：70%，97%）。计算的特异性为33%（95%可信区间：2%，79%），阴性预测值为25%（95%可信区间：1%，70%.CONCLUSION：这些初步数据表明PET乳腺摄影可以显示小原发性乳腺恶性肿瘤。(C)RSNA，2005年。
PURPOSE: To prospectively assess a dedicated, large field of view positron emission tomography (PET) mammographic device for imaging primary breast carcinoma.MATERIALS AND METHODS: Institutional review board approval was obtained for this study, and all patients provided written informed consent prior to participation. Subjects were recruited from a cohort of patients in whom diagnostic mammography and/or ultrasonography demonstrated lesions that were highly suggestive of malignancy. Twenty-three patients who met the inclusion criteria were subsequently imaged by using a dedicated PET mammography unit that was developed in conjunction with the Thomas Jefferson National Accelerator Facility (Newport News, Va). One hour after administration of 2.0-2.5 mCi (74.0-93.5 MBq) of fluorodeoxyglucose, 5-minute PET mammography of the affected breast was performed. Images were processed and reconstructed in the transverse craniocaudal and coronal planes. For each lesion, image-guided core-needle biopsy was performed immediately after PET mammography. Conventional mammography results and histologic findings were correlated with PET mammography images. The sensitivity, specificity, negative predictive value, and positive predictive value of PET mammography for demonstrating malignant lesions were calculated.RESULTS: PET mammography demonstrated 20 focal abnormalities, of which 18 were malignant and two were benign. Both benign lesions represented areas of fat necrosis. Three of 20 malignant lesions demonstrated at conventional mammography were not demonstrated at PET mammography. The overall sensitivity of PET mammography for malignancy was 86% (95% confidence interval: 65%, 95%), with a positive predictive value of 90% (95% confidence interval: 70%, 97%). The calculated specificity was 33% (95% confidence interval: 2%, 79%), and the negative predictive value was 25% (95% confidence interval: 1%, 70%).CONCLUSION: These pilot data suggest that PET mammography can demonstrate small primary breast malignancies. (C) RSNA, 2005.