Evi-1 expression in Xenopus
Evi-1 expression in Xenopus
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DOI：
10.1016/j.modgep.2005.03.007
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发表时间：
2005-06-01
影响因子：
1.2
通讯作者：
Ihle, JN
中科院分区：
文献类型：
--
作者：
Mead, PE;Parganas, E;Ihle, JN
Evi-1 基因首次被鉴定为小鼠髓系白血病中病毒整合的位点。 Evi-1 是一种锌指转录因子，与骨髓瘤的发展有关。在人类中，染色体重排导致的 Evi-1 位点破坏与骨髓性白血病和骨髓增生异常综合征有关。在这里，我们报告了 Xenopus Evi-1 的克隆和发育表达模式。 xEvi-1 在卵子发生和胚胎发育过程中表达。原位杂交揭示 xEvi-1 在早期胚胎发育过程中具有动态表达谱。通过原位杂交检测前肾组织、大脑以及头颈神经嵴衍生物中 Evi-1 的表达。 (c) 2005 Elsevier B.V. 保留所有权利。
The Evi-1 gene was first identified as a site for viral integration in murine myeloid leukemia. Evi-1 is a zinc finger transcription factor that has been implicated in the development of myeloid neoplasia. In humans, disruption of the Evi-1 locus, by chromosomal rearrangements, is associated with myeloid leukemia and myelodyplastic syndromes. Here, we report the cloning and developmental pattern of expression of Xenopus Evi-1. xEvi-1 is expressed during oogenesis and during embryonic development. In situ hydridization reveals that xEvi-1 has a dynamic expression profile during early embryonic development. Expression of Evi-1 is detected by in situ hybridization in the pronephric tissue, the brain and in neural crest derivatives of the head and neck. (c) 2005 Elsevier B.V. All rights reserved.