Ag-Initiated gem-Difluoromethylenation of the Nitrogen Center of Arenediazonium Salts to gem-Difluoromethylene Azo Compounds
Ag-Initiated gem-Difluoromethylenation of the Nitrogen Center of Arenediazonium Salts to gem-Difluoromethylene Azo Compounds
复制标题
Ag 引发芳烃重氮盐氮中心的偕二氟亚甲基化成偕二氟亚甲基偶氮化合物
DOI：
10.1021/acs.orglett.7b00936
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发表时间：
2017-05-05
期刊：
影响因子：
5.2
通讯作者：
Hao, Jian
中科院分区：
文献类型：
--
作者：
Jiang, Haizhen;Chen, Yunrong;Hao, Jian
An efficient method for the synthesis of the thermally stable and pharmaceutically important gem-difluoromethylene azo compounds is developed. This protocol achieved gem-difluoromethylenation of the nitrogen center of arenediazonium salts through in situ generated benzo-1,3-diazolic difluoromethylene radical addition to arenediazonium salts under mild Ag-initiated conditions.
