Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells.
Pathogenesis of chronic viral hepatitis: differential roles of T cells and NK cells.
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慢性病毒肝炎的发病机理：T细胞和NK细胞的差异作用。
作者：
慢性B型肝炎（HBV）和丙型肝炎病毒（HCV）感染占全世界肝硬化病例的57%和原发性肝癌病例的78%，并且每年导致一百万人死亡。虽然HBV和HCV在基因组结构、复制策略和生命周期方面存在差异，但它们具有共同的特征，包括它们的非细胞病变性质和诱导慢性肝病的能力，这被认为是免疫介导的。然而，从慢性肝炎到肝硬化的疾病进展速度在感染个体之间差异很大，并且调节它的因素在很大程度上是未知的。本文综述了我们目前对抗原特异性和非特异性免疫细胞在慢性B肝炎和丙型肝炎发病机制中的作用的认识，并讨论了最近的研究结果，确定自然杀伤细胞作为T细胞功能和肝脏炎症的调节剂。
Chronic hepatitis B (HBV) and hepatitis C virus (HCV) infections account for 57% of cases of liver cirrhosis and 78% of cases of primary liver cancer worldwide and cause a million deaths per year. Although HBV and HCV differ in their genome structures, replication strategies and life cycles, they have common features, including their noncytopathic nature and the capacity to induce chronic liver disease, which is thought to be immune-mediated. However, the rate of disease progression from chronic hepatitis to cirrhosis varies greatly among infected individuals, and the factors that regulate it are largely unknown. This review summarizes our current understanding of the roles of antigen-specific and nonspecific immune cells in the pathogenesis of chronic hepatitis B and C, and discusses recent findings that identify natural killer cells as regulators of T cell function and liver inflammation.
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影响因子：
15.3
作者：
Das, Abhishek;Hoare, Matthew;Davies, Nathan;Lopes, A. Ross;Dunn, Claire;Kennedy, Patrick T. F.;Alexander, Graeme;Finney, Helene;Lawson, Alistair;Plunkett, Fiona J.;Bertoletti, Antonio;Akbar, Arne N.;Maini, Mala K.
通讯作者：
Maini, Mala K.
DOI：
10.4049/jimmunol.0800997
发表时间：
2009-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bucks CM;Norton JA;Boesteanu AC;Mueller YM;Katsikis PD
通讯作者：
Katsikis PD
程序性死亡-1 及其配体在 HBV 相关慢性急性肝衰竭患者的肝内表达。
影响因子：
5.1
作者：
Cao, Dayan;Xu, Huan;Chen, Yongwen
通讯作者：
Chen, Yongwen
影响因子：
13.5
作者：
Chang, KM;Thimme, R;Chisari, FV
通讯作者：
Chisari, FV
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John