A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein
A function for kinesin I in the posterior transport of oskar mRNA and Staufen protein
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DOI：
10.1126/science.289.5487.2120
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发表时间：
2000-09-22
期刊：
影响因子：
56.9
通讯作者：
Saxton, WM
中科院分区：
文献类型：
--
作者：
Brendza, RP;Serbus, LR;Saxton, WM
信使RNA（mRNA）和蛋白质决定簇的不对称定位在建立复杂的身体计划中起着重要作用。在果蝇卵母细胞中，bicoid mRNA的前部定位和oskar mRNA的后部定位是建立前后轴的关键事件。虽然驱动bicoid和oskar定位的机制一直难以捉摸，但卵母细胞微管是必不可少的。在这里，我们报告说，正末端定向微管运动驱动蛋白1所需的奥斯卡mRNA和相关的蛋白质，施陶芬，但不为其他不对称因素的前后定位的后部定位。因此，含有oskar mRNA和Staufen的复合物可通过驱动蛋白I沿沿着转运至后极。
The asymmetric localization of messenger RNA (mRNA) and protein determinants plays an important role in the establishment of complex body plans. In Drosophila oocytes, the anterior localization of bicoid mRNA and the posterior Localization of oskar mRNA are key events in establishing the anterior-posterior axis. Although the mechanisms that drive bicoid and oskar Localization have been elusive, oocyte microtubules are known to be essential. Here we report that the plus end-directed microtubule motor kinesin 1 is required for the posterior Localization of oskar mRNA and an associated protein, Staufen, but not for the anterior-posterior localization of other asymmetric factors. Thus, a complex containing oskar mRNA and Staufen may be transported along microtubules to the posterior pole by kinesin I.