Treatment of hypertension and prevention of dementia.
Treatment of hypertension and prevention of dementia.
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DOI：
10.1016/j.jalz.2005.06.022
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发表时间：
2005-07-01
期刊：
影响因子：
--
通讯作者：
Forette, Francoise
中科院分区：
文献类型：
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作者：
Hanon, Olivier;Forette, Francoise
由于人口老龄化，痴呆症的频率在未来几年将急剧增加。预防认知障碍和痴呆症已成为一项重大的公共卫生挑战。高血压是脑血管疾病的主要危险因素，也与认知能力下降和痴呆密切相关。一些流行病学研究发现，认知功能通常与15年或20年前测量的血压值成反比。此外，抗高血压药物的使用已被证明有助于防止认知能力下降，为预防痴呆症（血管性或阿尔茨海默氏症型）开辟了道路。这些结果表明，痴呆的发病率应构成未来试验比较不同类别的抗高血压药物的主要结果。
Because of the aging population, the frequency of dementia will dramatically increase in the coming years. Prevention of cognitive disorders and dementia has become a major public health challenge. High blood pressure is a major risk factor for cerebrovascular diseases and is also correlated closely with cognitive decline and dementia. Several epidemiologic studies have found that cognitive functions are often inversely proportional to blood pressure values measured 15 or 20 years previously. Moreover, the use of antihypertensive drugs has been shown to help prevent cognitive decline, opening the way to the prevention of dementia (vascular or Alzheimer's type). These results indicate that incidence of dementia should constitute a major outcome of future trials comparing different classes of antihypertensive drugs.