Depression and endogenous melatonin in postmenopausal women
Depression and endogenous melatonin in postmenopausal women
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DOI：
10.1016/s0165-0327(01)00303-2
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发表时间：
2002-05-01
影响因子：
6.6
通讯作者：
Langer, RD
中科院分区：
文献类型：
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作者：
Tuunainen, A;Kripke, DF;Langer, RD
背景：以往关于抑郁症褪黑激素分泌的报道很多，但相互矛盾。很少有研究将夜间褪黑激素峰值的持续时间与抑郁症联系起来，这些研究的结果一直模棱两可。方法：我们研究了382名绝经后妇女的情绪障碍和尿褪黑激素排泄情况。根据DSM-IV轴I障碍（SCID）的结构化临床访谈确定精神病诊断和功能总体评估（GAF）评分。尿6-硫酸氧褪黑激素（6-SMT）样品收集了两个24小时的时间在家里。结果：抑郁症家族史与6-SMT排泄持续时间显著相关。即使在控制了年龄、种族、季节和几种药物的情况下，目前的抑郁症和6-SMT排泄延迟偏移之间以及晚期高峰期和终生抑郁症之间也存在轻微的显著相关性。局限性：受试者是在他们的家庭环境中进行研究的，那里的灯光效果不受控制。数据仅限于绝经后女性，包括有限数量的当前重度抑郁症受试者。结论：这些结果表明，可能有一个家族的脆弱性，在内源性褪黑激素信号的受试者容易抑郁症，和异常的褪黑激素信号的持续时间在那些与当前的抑郁症。(C)2002 Elsevier Science B. V.保留所有权利。
Background: Previous reports on melatonin secretion in depression are numerous but conflicting. There are very few studies relating the duration of the nocturnal melatonin peak to depression, and the results of those studies have been equivocal. Methods: We studied mood disorders and urinary melatonin excretion in 382 postmenopausal women. Psychiatric diagnoses and global assessment of functioning (GAF) scores were determined based on a Structured Clinical Interview for DSM-IV Axis I Disorders (SCID). Urinary 6-sulfatoxymelatonin (6-SMT) samples were collected for two 24-h periods at home. Results: A positive family history of depression was significantly related to a longer duration of 6-SMT excretion. There were marginally significant associations between current major depression and delayed offset of 6-SMT excretion and between later acrophase and lifetime major depression, even with control for age, ethnicity, season, and several medications. Limitations: The subjects were studied in their home environments, where light effects were not controlled. Data were restricted to postmenopausal women, including a limited number of subjects with current major depression. Conclusions: These results suggest that there might be a familial vulnerability in the endogenous melatonin signal in subjects prone to depression, and an abnormality in the duration of the melatonin signal in those with current major depression. (C) 2002 Elsevier Science B.V. All rights reserved.