Neural mechanism of cognitive control impairment in patients with hepatic cirrhosis: A functional magnetic resonance imaging study
Neural mechanism of cognitive control impairment in patients with hepatic cirrhosis: A functional magnetic resonance imaging study
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DOI：
10.1080/02841850701308378
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发表时间：
2007-01-01
期刊：
影响因子：
1.3
通讯作者：
Qi, Ji
中科院分区：
文献类型：
--
作者：
Zhang, Long Jiang;Yang, Guifen;Qi, Ji
背景：许多研究表明无明显肝性脑病（HE）的肝硬化患者存在注意力改变。这方面的功能磁共振成像（fMRI）研究尚未发表。目的：应用功能磁共振成像技术探讨肝硬化患者认知控制缺陷的神经基础。材料与方法：纳入14例肝硬化患者和14例健康志愿者。采用改进的Stroop汉字任务作为目标刺激，采用分块设计功能磁共振成像（fMRI）获取资源数据，包括4个刺激块和5个对照块，每个刺激块交替呈现。使用统计参数映射99进行图像分析。fMRI检查完成后，对所有受试者进行Stroop干扰行为测试。记录总反应时间和错误数。结果：健康志愿者和肝硬化患者均有Stroop干扰效应。肝硬化患者在执行不协调的颜色命名任务时比健康志愿者有更多的错误和更长的反应时间（P < 0.001）；在执行不一致的单词阅读任务方面，两组间无显著差异（P=0.066）。与对照组相比，肝硬化患者在执行不协调的单词阅读任务时，双侧前额叶皮层和顶叶皮层的激活程度更高。随着冲突的增加，当肝硬化患者执行不协调的颜色命名任务时，前扣带皮层（ACC）、双侧前额叶皮层（PFC）、顶叶和颞梭状回（TFG）的激活减少。结论：本研究证实肝硬化患者存在认知控制缺陷。ACC - PFC -顶叶- TFG脑网络异常是肝硬化患者认知控制功能障碍的神经基础。
Background: Many studies have claimed the existence of attention alterations in cirrhotic patients without overt hepatic encephalopathy ( HE). No functional magnetic resonance imaging ( fMRI) study in this respect has been published.Purpose: To investigate the neural basis of cognitive control deficiency in cirrhotic patients using fMRI.Material and Methods: 14 patients with hepatic cirrhosis and 14 healthy volunteers were included in the study. A modified Stroop task with Chinese characters was used as the target stimulus, and block-design fMRI was used to acquire resource data, including four stimulus blocks and five control blocks, each presented alternatively. Image analysis was performed using statistical parametric mapping 99. After fMRI examinations were complete, behavior tests of Stroop interference were performed for all subjects. Overall reaction time and error numbers were recorded.Results: Both healthy volunteers and patients with hepatic cirrhosis had Stroop interference effects. Patients with hepatic cirrhosis had more errors and longer reaction time in performing an incongruous color-naming task than healthy volunteers (P < 0.001); there was no significant difference in performing an incongruous word-reading task (P=0.066). Compared with controls, patients with hepatic cirrhosis had greater activation of the bilateral prefrontal cortex and parietal cortex when performing the incongruous word-reading task. With increased conflict, activation of the anterior cingulate cortex (ACC), bilateral prefrontal cortex (PFC), parietal lobe, and temporal fusiform gyrus (TFG) was decreased when patients with hepatic cirrhosis performed the incongruous color-naming task.Conclusion: This study demonstrates that patients with hepatic cirrhostic have cognitive control deficiency. The abnormal brain network of the ACC - PFC - parietal lobe - TFG is the neural basis of cognitive control impairment in cirrhotic patients.