Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.
Aging Changes in Retinal Microglia and their Relevance to Age-related Retinal Disease.
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DOI：
10.1007/978-3-319-17121-0_11
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发表时间：
2016
影响因子：
--
通讯作者：
Wong WT
中科院分区：
文献类型：
--
作者：
Ma W;Wong WT
视网膜相关性视网膜疾病，如年龄相关性黄斑变性（AMD）和青光眼，含有可促进疾病进展的慢性视网膜炎症的特征。然而，衰老和神经炎症之间的关系尚不清楚。小胶质细胞是视网膜的长寿的常驻免疫细胞，并且介导局部神经炎症反应。我们推测，小胶质细胞的老化变化可能与年龄依赖性视网膜疾病的神经炎症变化有因果关系。在这里，我们回顾了以下证据：（1）视网膜小胶质细胞表型如何随衰老而变化，（2）驱动视网膜小胶质细胞衰老的因素，以及（3）小胶质细胞基因表达的衰老相关变化。我们研究这些方面的小胶质细胞老化的变化可能与免疫失调的致病机制，驱动年龄相关的视网膜疾病的进展。这些关系可以突出小胶质细胞老化作为预防和治疗视网膜疾病的新靶点。
Age-related retinal diseases, such as age-related macular degeneration (AMD) and glaucoma, contain features of chronic retinal inflammation that may promote disease progression. However, the relationship between aging and neuroinflammation is unclear. Microglia are long-lived, resident immune cells of the retina, and mediate local neuroinflammatory reactions. We hypothesize that aging changes in microglia may be causally linked to neuroinflammatory changes underlying age-dependent retinal diseases. Here, we review the evidence for (1) how the retinal microglial phenotype changes with aging, (2) the factors that drive microglial aging in the retina, and (3) aging-related changes in microglial gene expression. We examine how these aspects of microglial aging changes may relate to pathogenic mechanisms of immune dysregulation driving the progression of age-related retinal disease. These relationships can highlight microglial aging as a novel target for the prevention and treatment of retinal disease.