Waist circumference and BMI cut-off based on 10-year cardiovascular risk: Evidence for "Central Pre-Obesity"
Waist circumference and BMI cut-off based on 10-year cardiovascular risk: Evidence for "Central Pre-Obesity"
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DOI：
10.1038/oby.2007.336
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发表时间：
2007-11-01
期刊：
影响因子：
6.9
通讯作者：
Tang, Joyce S. F.
中科院分区：
文献类型：
--
作者：
Ko, Gan T. C.;Tang, Joyce S. F.
目的：目的是评估腰围（WC）的截止点，最好地确定一个水平的10年心血管疾病（CVD）的风险与最佳平衡的敏感性和特异性在中国subjects.Research方法和程序的敏感性和特异性根据其预测的10年CVD risk。计算了基于各种预测模型的10年CVD风险。结果：共有4837名（32.4%）男性和10,082名（67.6%）女性（平均英亩标准差，47.3 +/-13.5岁;年龄范围，18至93岁;中位年龄，45.0岁）。预测10年CVD风险为15%至30%的平均最佳WC或BMI分别为男性83至88 cm和25 kg/m2，女性76 cm和23 kg/m2。当男性腰围>= 90 cm，女性腰围>= 80 cm时，在不同的腰围临界点，男性发生10年心血管疾病风险>= 20%的可能性比为1.5 - 2.0，女性为3.0。男性的似然比为1.5，WC在84厘米，女性在70厘米。讨论：我们的研究结果同意本指南的定义，在亚太地区的一般和中央肥胖。我们建议建立一个中间状态的高WC，"中心前期肥胖"的中国男性WC>= 84至90厘米（>= 33至36英寸）和女性WC>= 74至80厘米（>= 29至32英寸）。中心性肥胖前期患者与超重患者（BMI>= 23至25 kg/m2）相似，合并症的风险已经增加。
Objective: The objective was to assess the waist circumference (WC) cut-off point that best identifies a level of 10-year cardiovascular disease (CVD) risk with optimal balance of sensitivity and specificity in Chinese subjects according to their predicted 10-year CVD risk.Research Methods and Procedures: A community-based cross-sectional observational study involving 14,919 Hong Kong Chinese subjects. The 10-year CVD risk based on various prediction models was calculated. The projected WC cut-off points were then determined.Results: There were 4837 (32.4%) men and 10,082 (67.6%) women (mean acre standard deviation, 47.3 +/- 13.5 years; age range, 18 to 93 years; median age, 45.0 years). The mean optimal WC or BMI predicting a 15% to 30% 10-year CVD risk were 83 to 88 cm and 25 kg/m(2) for men, and 76 cm and 23 kg/m(2) for women, respectively. With WC >= 90 cm in men and >= 80 cm in women, the likelihood ratio at various WC cut-off points to develop a >= 20% 10-year CVD risk is 1.5 to 2.0 in men and 3.0 in women. The likelihood ratio was 1.5 in men with WC at 84 cm and in women at 70 cm.Discussion: Our results agree with the present guidelines on the definition of general and central obesity in Asia-Pacific regions. We propose the creation of an intermediate state of high WC, the "central pre-obesity" for Chinese men with WC >= 84 to 90 cm ( >= 33 to 36 inches) and women with WC >= 74 to 80 cm (>= 29 to 32 inches). People with central pre-obesity, similar to those with overweight (BMI >= 23 to 25 kg /m(2)), already have an increased risk of co-morbidities.