Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth
Association of maternal IL-1 receptor antagonist intron 2 gene polymorphism and preterm birth
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DOI：
10.1016/j.ajog.2006.09.002
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发表时间：
2006-11-01
影响因子：
9.8
通讯作者：
Heine, R. Phillips
中科院分区：
文献类型：
--
作者：
Murtha, Amy P.;Nieves, Angel;Heine, R. Phillips
目的：本研究旨在确定白介素 1 受体拮抗剂 (IL-1RN) 可变数量串联重复多态性是否与早产相关。研究设计：进行了病例对照研究。病例 (n = 95) 在早产 (PTL) 或早产胎膜早破 (PPROM) 后 37 周前分娩，对照组 (n = 105) 在 37 周后分娩。通过聚合酶链式反应对母体 DNA 进行基因分型，以检测 IL-1RN 基因内含子 2 的长度多态性。结果：各组间母体年龄、种族、保险状况或胎次没有显着差异。在总组和研究组中，等位基因和基因型频率与 Hardy-Weinberg 平衡下预期的频率 (P = .59) 没有显着差异。在 95 例病例中，26.8% 的患者至少存在 1 个等位基因 2 拷贝，而对照组这一比例为 12.4% (P < .0004)。结论：母亲携带至少 I 个 IL-1RN 等位基因 2 拷贝似乎与早产风险增加相关。 (c) 2006 Mosby, Inc. 保留所有权利。
Objective: This study was undertaken to determine whether the interleukin-1 receptor antagonist (IL-1RN) variable number tandem repeat polymorphism is associated with preterm birth.Study design: A case-control study was performed. Cases (n = 95) delivered before 37 weeks after preterm labor (PTL) or preterm premature rupture of membranes (PPROM) and controls (n = 105) delivered after 37 weeks. Maternal DNA was genotyped by polymerase chain reaction for a length polymorphism in intron 2 of the IL-1RN gene.Results: There was no significant difference in maternal age, ethnicity, insurance status, or parity between groups. Allele and genotype frequencies did not differ significantly from that expected under Hardy-Weinberg equilibrium (P = .59) in the total group as well as study groups. Of the 95 cases, 26.8% had at least 1 copy of allele 2 present compared with 12.4% in the control group (P < .0004).Conclusion: Maternal carriage of at least I copy of the IL-1RN allele 2 appears to be associated with increased risk of preterm birth. (c) 2006 Mosby, Inc. All rights reserved.