Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
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DOI：
10.1126/science.1130042
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发表时间：
2006-09-08
期刊：
影响因子：
56.9
通讯作者：
Rijli, Filippo M.
中科院分区：
文献类型：
--
作者：
Oury, Franck;Murakami, Yasunori;Rijli, Filippo M.
在小鼠三叉神经通路中，来自不同面部结构的感觉输入，如胡须或下巴和嘴唇，通过丘脑和后脑的中继站被地形图映射到躯体感觉皮质。在发育中的后脑中，生成这种地图的机制仍然难以捉摸。我们发现，在主要感觉核中，与胡须相关的MAP由菱形3派生的神经元提供，而菱形2派生的后代提供下颌骨和嘴唇的表征。此外，Hoxa2在神经上皮细胞中的早期表达阻止了三叉神经异位投射到小脑，而在主要感觉核中的晚期表达促进了胡须相关传入的选择性树枝分布和与丘脑的局部连接。Hoxa2的失活进一步导致出生后大脑中缺乏与胡须相关的图谱。因此，依赖于Hoxa2和菱形3的线索决定了胡须区域图，并且是组装胡须到桶的体感电路所必需的。
In the mouse trigeminal pathway, sensory inputs from distinct facial structures, such as whiskers or lower jaw and lip, are topographically mapped onto the somatosensory cortex through relay stations in the thalamus and hindbrain. In the developing hindbrain, the mechanisms generating such maps remain elusive. We found that in the principal sensory nucleus, the whisker-related map is contributed by rhombomere 3 - derived neurons, whereas the rhombomere 2 - derived progeny supply the lower jaw and lip representation. Moreover, early Hoxa2 expression in neuroepithelium prevents the trigeminal nerve from ectopically projecting to the cerebellum, whereas late expression in the principal sensory nucleus promotes selective arborization of whisker-related afferents and topographic connectivity to the thalamus. Hoxa2 inactivation further results in the absence of whisker-related maps in the postnatal brain. Thus, Hoxa2- and rhombomere 3 - dependent cues determine the whisker area map and are required for the assembly of the whisker-to-barrel somatosensory circuit.