The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine
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DOI：
10.1152/ajpgi.00321.2010
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发表时间：
2010-11-01
影响因子：
4.5
通讯作者：
Yun, C. Chris
中科院分区：
文献类型：
--
作者：
Lin, Songbai;Lee, Sei-Jung;Yun, C. Chris
林 S、李 S、沉 H、Chun J、Yun CC。 LPA 受体 2 的缺失可减少肠道中 Apc(Min) 突变导致的肿瘤发生。 Am J Physiol Gastrointest Liver Physiol 299：G1128-G1138，2010。首次发表于 2010 年 8 月 19 日； doi: 10.1152/ajpgi.00321.2010.-溶血磷脂酸 (LPA) 是一种脂质介质，可介导多种促进癌症进展的作用。 LPA 受体 2 型 (LPA(2)) 表达在多种癌症中通常升高，包括结直肠癌 (CRC)。在本研究中，我们通过比较Apc(Min/+)小鼠和Apc(Min/+)/Lpar2(-/-)小鼠，研究了LPA(2)在肠腺瘤发生中的作用。 Apc(Min/+)/Lpar2(-/-) 小鼠的肠道腺瘤比 Apc(Min/+) 小鼠少 50%。较小尺寸的腺瘤（
Lin S, Lee S, Shim H, Chun J, Yun CC. The absence of LPA receptor 2 reduces the tumorigenesis by Apc(Min) mutation in the intestine. Am J Physiol Gastrointest Liver Physiol 299: G1128-G1138, 2010. First published August 19, 2010; doi: 10.1152/ajpgi.00321.2010.-Lysophosphatidic acid (LPA) is a lipid mediator that mediates several effects that promote cancer progress. The LPA receptor type 2 (LPA(2)) expression is often elevated in several types of cancers, including colorectal cancer (CRC). In this study, we investigated the role of LPA(2) in the development of intestinal adenomas by comparing Apc(Min/+) mice with Apc(Min/+)/Lpar2(-/-) mice. There were 50% fewer intestinal adenomas in Apc(Min/+)/Lpar2(-/-) mice than Apc(Min/+) mice. Smaller-size adenomas (