Physical symptoms in long-term survivors of rare cancer.
Physical symptoms in long-term survivors of rare cancer.
复制标题
罕见癌症长期幸存者的身体症状。
DOI：
10.1007/s11764-018-0721-9
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Finkelstein,DianneM
中科院分区：
文献类型：
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作者：
Horick,NoraK;Muzikansky,Ariela;Gutierrez,HildaL;Boyd,KristinaL;Finkelstein,DianneM
癌症检测和治疗的进展导致长期幸存者人数不断增加，但即使在治疗结束后数年，许多幸存者报告的身体症状干扰了日常生活。虽然有关于常见癌症的晚期效应的研究，但对罕见癌症的这些并发症知之甚少。本研究的重点是身体症状的长期生存者在NIH赞助的罕见癌症遗传学Registry.MethodsThe鹿特丹症状检查表修改后的报告进行管理，以评估身体症状的严重程度，通常报告的长期癌症幸存者。Logistic回归被用来评估症状和人口统计学和临床factors.ResultsIn 309例中位时间为7.6年，从一个或多个罕见的癌症的诊断，目前每个参与者的症状的中位数为7。报告的最常见症状是疲劳/缺乏能量，这在70%/25%的注册者中存在/非常麻烦。女性，非白人，当前吸烟者和上消化道癌症幸存者尤其受影响。总体而言，症状患病率在罕见癌症类型，诊断后的时间和治疗类型之间相似。结论罕见癌症幸存者在诊断后多年继续经历麻烦的症状，无论癌症类型或治疗方式如何。对癌症幸存者的影响有必要继续强调癌症幸存者的戒烟以及加强对女性，非白人，和上消化道癌症幸存者
PurposeAdvances in cancer detection and treatment have resulted in a growing population of long-term survivors, but even years after treatment has concluded, many survivors report physical symptoms that interfere with daily living. While there are studies of late effects following common cancers, less is known about these complications in rare cancers. This study focuses on the physical symptoms reported by long-term survivors enrolled in the NIH-sponsored Rare Cancer Genetics Registry.MethodsThe Rotterdam Symptom Checklist-Modified was administered to evaluate the severity of physical symptoms commonly reported by long-term cancer survivors. Logistic regression was used to assess association between symptoms and demographic and clinical factors.ResultsIn 309 subjects with a median time of 7.6 years from a diagnosis of one or more rare cancers, the median number of symptoms present per participant was 7. The most prevalent symptom reported was tiredness/lack of energy, which was present/very bothersome in 70%/25% of registrants. Women, non-whites, current smokers, and upper GI cancer survivors are particularly affected. Overall, symptom prevalence was similar across rare cancer types, time since diagnosis, and type of treatment.ConclusionsRare cancer survivors continue to experience troublesome symptoms many years after diagnosis, regardless of cancer type or treatment modality.Implications for Cancer SurvivorsThere is a need for continued emphasis on smoking cessation in cancer survivors as well as enhanced monitoring of long-term complications in female, non-white, and upper GI cancer survivors.