Lipid droplet dynamics in alcoholic fatty liver disease.
Lipid droplet dynamics in alcoholic fatty liver disease.
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DOI：
10.1016/j.livres.2019.09.002
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发表时间：
2019-12
期刊：
影响因子：
--
通讯作者：
Ding WX
中科院分区：
文献类型：
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作者：
Schulze RJ;Ding WX
酒精相关性肝病（ALD）发病率的上升要求在了解酒精相关性肝细胞损伤的基本分子基础方面取得紧急进展。长期饮酒伴随的关键早期事件之一是肝细胞细胞质中脂滴（LD）的积累。 LD 远离中性脂质储存的惰性场所；相反，它们代表了在细胞代谢状态中发挥重要作用的关键细胞器。在这篇综述中，我们将研究这些结构的生物学，并概述最近为了解酒精暴露对 LD 的生物发生、分解代谢和运动的影响以及它们的动态性质在 ALD 背景下如何受到干扰而所做的努力。
The rising incidence of alcohol-related liver disease (ALD) demands making urgent progress in understanding the fundamental molecular basis of alcohol-related hepatocellular damage. One of the key early events accompanying chronic alcohol usage is the accumulation of lipid droplets (LDs) in the hepatocellular cytoplasm. LDs are far from inert sites of neutral lipid storage; rather, they represent key organelles that play vital roles in the metabolic state of the cell. In this review, we will examine the biology of these structures and outline recent efforts being made to understand the effects of alcohol exposure on the biogenesis, catabolism, and motility of LDs and how their dynamic nature is perturbed in the context of ALD.