Histological findings after brown recluse spider envenomation
Histological findings after brown recluse spider envenomation
复制标题
DOI：
10.1097/00000372-200006000-00006
复制
发表时间：
2000-06-01
影响因子：
1.1
通讯作者：
Fischer, JR
中科院分区：
文献类型：
--
作者：
Elston, DM;Eggers, JS;Fischer, JR
对41只兔的组织学标本进行了研究，观察了人工注射棕色隐匿性蜘蛛毒液引起的变化。主要表现包括混合性炎细胞浸润、凝固性组织坏死和血管炎。所有标本均显示一个清晰的嗜酸性染色区域，可辨认为表皮和真皮的“木乃伊化”凝固性坏死。坏死区周围有致密的中性粒细胞带。紧邻中性粒细胞带的小血管炎是一个普遍的发现。脱颗粒的嗜酸性粒细胞和中性粒细胞以及充满嗜酸性颗粒的巨噬细胞是常见的。炎性病灶通常集中在真皮内的脂肪细胞群上。在40个焦痂中，有7个深部可见与结节性多动脉炎相似的大血管血管炎。大血管血管炎可能是一些棕色隐居蜘蛛叮咬后出现大片坏死区的原因之一。嗜酸性粒细胞可能在毒化后的组织损伤中起作用。
Histologic specimens from 41 rabbits were studied for changes resulting from the manual injection of brown recluse spider venom. Major findings included a mixed inflammatory cell infiltrate, coagulative tissue necrosis, and vasculitis. All specimens demonstrated a well-delineated zone of eosinophilic staining recognizable as "mummified" coagulative necrosis of the epidermis and dermis. A dense band of neutrophils bordered the zone of necrosis. Immediately adjacent to the neutrophilic band, small vessel vasculitis was a universal finding. Degranulated eosinophils and neutrophils and macrophages filled with eosinophilic granules were common. Inflammatory foci were often centered on groups of lipocytes within the dermis. Large vessel vasculitis resembling that seen in polyarteritis nodosa was present deep to 7 of the 40 eschars. Large vessel vasculitis may contribute to the large zones of necrosis seen after some brown recluse spider bites. Eosinophils may play a role in tissue damage after envenomation.