Osteoarthritis
Osteoarthritis
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DOI：
10.1016/s0140-6736(14)60802-3
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发表时间：
2015-07-25
期刊：
影响因子：
168.9
通讯作者：
Carr, A. J.
中科院分区：
文献类型：
--
作者：
Glyn-Jones, S.;Palmer, A. J. R.;Carr, A. J.
骨关节炎是全球疼痛、残疾和社会经济成本的主要来源。该疾病的流行病学是复杂的和多因素的，具有遗传、生物和生物力学成分。病因因素也是关节特异性的。关节置换术是一种有效的治疗症状性终末期疾病，虽然功能结果可能很差，假体的寿命是有限的。因此，重点转向疾病预防和早期骨关节炎的治疗。这项任务是具有挑战性的，因为传统的成像技术只能检测到相当先进的疾病和疼痛和结构退化之间的关系并不密切。尽管如此，影像学和生化标志物的进展为诊断和新治疗的结果测量提供了可能。正在开发的保留关节的干预措施包括改变生活方式以及药物和手术方式。有些显示出潜力，但目前很少有证明有能力阻止或延缓疾病进展。
Osteoarthritis is a major source of pain, disability, and socioeconomic cost worldwide. The epidemiology of the disorder is complex and multifactorial, with genetic, biological, and biomechanical components. Aetiological factors are also joint specific. Joint replacement is an effective treatment for symptomatic end-stage disease, although functional outcomes can be poor and the lifespan of prostheses is limited. Consequently, the focus is shifting to disease prevention and the treatment of early osteoarthritis. This task is challenging since conventional imaging techniques can detect only quite advanced disease and the relation between pain and structural degeneration is not close. Nevertheless, advances in both imaging and biochemical markers off er potential for diagnosis and as outcome measures for new treatments. Joint-preserving interventions under development include lifestyle modification and pharmaceutical and surgical modalities. Some show potential, but at present few have proven ability to arrest or delay disease progression.