Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tract

Emerging questions regarding eosinophil's role in the esophago-gastrointestinal tract
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关于嗜酸性粒细胞在食管胃肠道中的作用的新问题

DOI:
10.1097/01.mog.0000245530.35518.3e
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发表时间:
2006
影响因子:
2.5
通讯作者:
G. Furuta
G. Furuta
中科院分区:
医学4区
文献类型:
--
作者:
G. Furuta

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胃肠道嗜酸性粒细胞性炎症的发生频率增加或得到更好的认识。无论是哪种情况,临床需要迎接这一新的挑战,包括建立诊断标准,确定自然史和确定有效的,可耐受的治疗方法。最近的发现在过去的5年中,嗜酸性食管炎的出现刺激了许多病例系列;新的前沿涉及了解疾病的发病机制和维持治疗。嗜酸性粒细胞性胃肠道疾病涉及胃肠道的其余部分提出了新的挑战,在理解的作用,嗜酸性粒细胞在肠道动力障碍和蛋白质丢失。本文将重点介绍嗜酸性粒细胞性胃肠道疾病的临床新进展,以及基础研究在了解嗜酸性粒细胞对胃肠道炎症的影响方面的贡献。
Purpose of review Eosinophilic inflammation of the gastrointestinal tract is either increasing in frequency or being better recognized. Whichever is the case, clinical needs to meet this new challenge include establishing diagnostic criteria, identifying the natural history and determining effective, tolerable treatments. Recent findings During the last 5 years, the emergence of eosinophilic esophagitis stimulated many case series; the new frontiers relate to understanding disease pathogenesis and maintenance treatments. Eosinophilic gastrointestinal diseases involving the rest of the gastrointestinal tract pose new challenges in understanding the role of eosinophils in intestinal dysmotility and protein loss. Summary This review will focus on new clinical developments in the field of eosinophilic gastrointestinal diseases and the contribution of basic studies in understanding eosinophils impact on gastrointestinal inflammation.
DOI: 10.1016/j.jaci.2004.02.021
发表时间: 2003-12
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