Normal range of anti-thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population: A cross-sectional study.
Normal range of anti-thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population: A cross-sectional study.
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DOI：
10.1097/md.0000000000022214
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发表时间：
2020-09-18
期刊：
影响因子：
1.6
通讯作者：
Hayashida N
中科院分区：
文献类型：
--
作者：
Shimizu Y;Kawashiri SY;Noguchi Y;Nagata Y;Maeda T;Hayashida N
抗甲状腺过氧化物酶抗体（TPO-Ab）是自身免疫性甲状腺疾病的已知原因，可增强促炎细胞因子反应。由于低度炎症是动脉粥样硬化的已知危险因素，因此在甲状腺功能正常的参与者中，正常范围的TPO-Ab（TPO-Ab阴性）可能与动脉粥样硬化呈正相关。然而，没有研究报道正常甲状腺参与者中TPO-Ab正常范围与动脉粥样硬化之间的关联。对1165名甲状腺功能正常（即游离三碘甲状腺原氨酸[游离T3]和游离甲状腺素[游离T4]的正常范围）的日本人进行了一项横断面研究，年龄为40至74岁，他们参加了2014年的年度健康检查。在研究人群中，115人被诊断为动脉粥样硬化。TPO-Ab滴度的正常范围值与动脉粥样硬化呈正相关;性别、年龄、甲状腺功能（游离T3和促甲状腺激素）和已知心血管危险因素校正的动脉粥样硬化对数值的比值比和95%置信区间为2.23（1.11，4.47）。当我们将分析限制在促甲状腺激素水平正常的参与者时，这种关联变得稍微强一些（2.65 [1.27，5.51]）。在甲状腺功能正常的一般人群中，TPO抗体滴度的正常范围与动脉粥样硬化呈正相关。尽管TPO-Ab滴度与临床无关，也与自身免疫性甲状腺疾病无关，但它可能影响内皮重塑，包括动脉粥样硬化。
Anti–thyroid peroxidase antibody (TPO-Ab), which is the known cause of autoimmune thyroid disease, enhances proinflammatory cytokine responses. Since low-grade inflammation is a known risk factor for atherosclerosis, a normal range of TPO-Ab (TPO-Ab negative) could be positively associated with atherosclerosis among participants with normal thyroid function. However, no study reported the association between normal range of TPO-Ab and atherosclerosis among eu-thyroid participants. A cross-sectional study was conducted with 1165 Japanese individuals with normal thyroid function (ie, normal range of free triiodothyronine [free T3] and free thyroxine [free T4]), aged 40 to 74 years, who participated in an annual health checkup in 2014. Among the study population, 115 were diagnosed as having atherosclerosis. A normal range value of TPO-Ab titer is revealed to be positively associated with atherosclerosis; sex, age, thyroid function (free T3 and thyroid-stimulating hormone), and known cardiovascular risk factor adjusted odds ratio and 95% confidence interval of atherosclerosis for logarithmic values of TPO-Ab was 2.23 (1.11, 4.47). When we limited the analysis to participants with normal levels of thyroid-stimulating hormone, this association became slightly stronger (2.65 [1.27,5.51]). Among the eu-thyroid general population, a normal range of TPO-Ab titer is revealed to be positively associated with atherosclerosis. Even though a TPO-Ab titer is not clinically relevant and is not associated with autoimmune thyroid disease, it could influence endothelial remodeling including atherosclerosis.