Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: An experimental study in rhesus monkeys
Optic disk and retinal nerve fiber layer damage after transient central retinal artery occlusion: An experimental study in rhesus monkeys
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DOI：
10.1016/s0002-9394(00)00384-6
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发表时间：
2000-06-01
影响因子：
4.2
通讯作者：
Jonas, JB
中科院分区：
文献类型：
--
作者：
Hayreh, SS;Jonas, JB
目的：评价中老年已存在动脉粥样硬化和高血压的恒河猴视网膜对急性缺血性损伤的耐受时间。方法：对39只平均年龄19.5±2.8岁的中老年恒河猴39只眼，在视神经硬膜鞘入口处临时夹持视网膜中央动脉97 ~ 300分钟，造成视网膜中央动脉闭塞。视网膜中央动脉闭塞前进行立体彩色眼底摄影和荧光素眼底血管造影。通过对比视网膜中央动脉闭塞前眼底彩色照片与研究结束时眼底彩色照片的形态计量学评价，评估视网膜神经纤维层损伤及视盘改变。结果：视网膜中央动脉闭塞时间与视网膜神经纤维层可见度降低（P = 0.018）、视盘苍白度加重（P = 0.014）有显著相关性；视网膜残余循环与视网膜神经纤维层可见度降低（P = 0.085）、视盘苍白度降低（P = 0.162）有显著相关性。然而，即使在视网膜中央动脉闭塞持续时间相似的眼睛中，视网膜中央动脉闭塞的长度和视盘苍白增加的程度以及视网膜神经纤维层可见性降低之间存在显著的个体差异。视网膜中央动脉闭塞时间在240分钟及以上的所有眼均出现完全或几乎全部视神经萎缩和神经纤维损伤。结论：本研究结果，与我们之前对年轻健康恒河猴的研究结果相比，表明中老年动脉粥样硬化和动脉高血压恒河猴，视网膜中央动脉闭塞小于100分钟，没有明显的视神经损伤形态学证据；然而，视网膜中央动脉阻塞105分钟但小于240分钟产生不同程度的损伤；视网膜中央动脉闭塞240分钟或更长时间，造成全部或几乎全部视神经萎缩和神经纤维损伤。(C) 2000年Elsevier Science inc .版权所有
PURPOSE: To evaluate the retinal tolerance time to acute ischemic insult in middle aged or elderly rhesus monkeys with pre-existing atherosclerosis and arterial hypertension.METHODS: In 39 eyes of 39 middle-aged and elderly rhesus monkeys with a mean age of 19.5 +/- 2.8 years, occlusion of the central retinal artery was produced by temporary clamping of the central retinal artery at its site of entry into the dural sheath of the optic nerve for 97 to 300 minutes. Stereoscopic color fundus photography and fluorescein fundus angiography were performed before central retinal artery occlusion and serially thereafter. Retinal nerve fiber layer damage and optic disk changes were assessed by comparing morphometric evaluation of the color fundus photographs taken before central retinal artery occlusion and color fundus photographs taken at the end of the study.RESULTS: There was a significant correlation between duration of central retinal artery occlusion and decreased visibility of retinal nerve fiber layer (P = .018) and increasing optic disk pallor (P = .014), and a trend between residual retinal circulation and decreased visibility of retinal nerve fiber layer (P = .085) and optic disk pallor (P = .162). However, there was a marked interindividual variation between the length of central retinal artery occlusion and degree of increased optic disk pallor and decreased visibility of the retinal nerve fiber layer, even among eyes with similar duration of central retinal artery occlusion. Complete or almost total optic nerve atrophy and nerve fiber damage were present in all eyes in which the duration of central retinal artery occlusion was 240 minutes or more.CONCLUSIONS: The findings of this study, compared with our previous study in young healthy rhesus monkeys, indicate that in middle-aged or elderly atherosclerotic and arterial hypertensive rhesus monkeys, central retinal artery occlusion for less than 100 minutes produced no apparent morphometric evidence of optic nerve damage; however, central retinal artery occlusion of 105 minutes but less than 240 minutes produced a variable degree of damage; central retinal artery occlusion for 240 minutes or more produced total or almost total optic nerve atrophy and nerve fiber damage. (C) 2000 by Elsevier Science inc, All rights reserved.