RADIATION RETINOPATHY AS AN EXPERIMENTAL-MODEL FOR ISCHEMIC PROLIFERATIVE RETINOPATHY AND RUBEOSIS IRIDIS
RADIATION RETINOPATHY AS AN EXPERIMENTAL-MODEL FOR ISCHEMIC PROLIFERATIVE RETINOPATHY AND RUBEOSIS IRIDIS
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DOI：
10.1016/s0002-9394(14)74395-8
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发表时间：
1987-06-15
影响因子：
4.2
通讯作者：
WOOD, IS
中科院分区：
文献类型：
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作者：
IRVINE, AR;WOOD, IS
我们用卷尾猴制作了放射性视网膜病变模型，并用荧光素血管造影术、光镜和电子显微镜对其进行了研究。这些动物在辐射后10天至3年半期间被跟踪观察，以确定这是否可以为其他慢性缺血-增殖性视网膜病变提供实验模型，如糖尿病。放射后发现的第一个变化是毛细血管内皮细胞和周细胞局灶性丢失。随着脱细胞毛细血管的区域变得融合，检眼镜上可见棉花斑点。它们的数量增加，然后逐渐消失，留下了大片的视网膜毛细血管灌注区。组织学研究显示，首先是较深、较小的视网膜血管闭塞，然后是较大的血管逐渐闭塞。随后发展了视网膜内新生血管和明显的再通，但没有新的血管通过内限板延伸到玻璃体。虹膜红斑症合并新生血管性青光眼，放射治疗后2 1/2~3 1/2年，玻璃体抽吸物中血管生成因子水平较高。
We produced radiation retinopathy in capuchin monkeys and studied them with fluorescein angiography and light and electron microscopy. The animals were followed up from ten days to 3 1/2 years after radiation in order to determine whether this could provide an experimental model for other chronic ischemic-proliferative retinopathies, such as diabetes. The first change detected after radiation was the focal loss of capillary endothelial cells and pericytes. As the areas of acellular capillaries became confluent, cotton-wool spots became visible ophthalmoscopically. These increased in number and then faded away, leaving large areas of retinal capillary perfusion. Histologic studies showed occlusion first of the deeper, smaller retinal vessels and then gradually of the larger vessels. Intraretinal neovascularization as well as apparent recanalization then developed, but no new vessels extended through the internal limiting lamina into the vitreous. Rubeosis iridis with neovascular glaucoma, developed 2 1/2 to 3 1/2 years postirradiation, and vitreous aspirate demonstrated a high level of angiogenic factor.