The very low density lipoprotein (VLDL) receptor - a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues
The very low density lipoprotein (VLDL) receptor - a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues
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DOI：
10.1023/a:1024184201941
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发表时间：
2003-06-01
影响因子：
4.3
通讯作者：
Yamamoto, TT
中科院分区：
文献类型：
--
作者：
Takahashi, S;Sakai, J;Yamamoto, TT
极低密度脂蛋白（VLDL）受体是低密度脂蛋白（LDL）受体家族的成员。VLDL受体结合载脂蛋白（apo）E，但不结合apo B，并在脂肪酸活性组织（心脏、肌肉、脂肪）和巨噬细胞中大量表达。脂蛋白脂酶（LPL）调节富含甘油三酯（TG）的脂蛋白颗粒与VLDL受体的结合。VLDL受体由于其独特的配体特异性，在外周组织中与LPL共同发挥IDL和乳糜微粒受体的功能。与LDL受体相反，VLDL受体表达不受脂蛋白下调。近年来，VLDL受体在脂蛋白代谢、动脉粥样硬化、肥胖/胰岛素抵抗、心脏脂肪酸代谢和神经元迁移中的几种可能的功能已被报道。将VLDL受体基因导入LDL受体基因敲除小鼠肝脏，对脂蛋白代谢和动脉粥样硬化有明显的改善作用。对VLDL受体功能的研究有待于进一步深入。
The VLDL (very low density lipoprotein) receptor is a member of the LDL (low density lipoprotein) receptor family. The VLDL receptor binds apolipoprotein ( apo) E but not apo B, and is expressed in fatty acid active tissues ( heart, muscle, adipose) and macrophages abundantly. Lipoprotein lipase (LPL) modulates the binding of triglyceride (TG)- rich lipoprotein particles to the VLDL receptor. By the unique ligand specificity, VLDL receptor practically appeared to function as IDL ( intermediate density lipoprotein) and chylomicron remnant receptor in peripheral tissues in concert with LPL. In contrast to LDL receptor, the VLDL receptor expression is not down regulated by lipoproteins. Recently several possible functions of the VLDL receptor have been reported in lipoprotein metabolism, atherosclerosis, obesity/insulin resistance, cardiac fatty acid metabolism and neuronal migration. The gene therapy of VLDL receptor into the LDL receptor knockout mice liver showed a benefit effect for lipoprotein metabolism and atherosclerosis. Further researches about the VLDL receptor function will be needed in the future.