Nanometric Micelles with Photo-Triggered Cytotoxicity
Nanometric Micelles with Photo-Triggered Cytotoxicity
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DOI：
10.1002/adfm.201400840
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发表时间：
2014-09-01
影响因子：
19
通讯作者：
Doris, Eric
中科院分区：
文献类型：
--
作者：
Anilkumar, Parambath;Gravel, Edmond;Doris, Eric
本文报道了一种能够触发细胞死亡的光响应胶束系统的研制。胶束的前体是通过将亲脂性链经由光不稳定的硝基苄基连接到亲水性聚乙二醇来合成的。所得的两亲性单元在水中自组装，形成易于内化到细胞中的12 nm胶束。在光照射后，胶束经历裂解并产生细胞毒性的亚硝基苯甲醛衍生物，其在标准体外条件下显著抑制MDA-MB-231细胞的增殖。
The development of a photo-responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photolabile nitrobenzyl group. The resulting amphiphilic units are self-assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo-irradiation, micelles undergo cleavage and yield a cytotoxic nitrosobenzaldehyde derivative, which significantly inhibits the proliferation of MDA-MB-231 cells under standard in vitro conditions.