The other myeloperoxidase: Emerging functions
The other myeloperoxidase: Emerging functions
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DOI：
10.1016/j.abb.2018.03.037
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发表时间：
2018-07-01
影响因子：
3.9
通讯作者：
Delporte, Cedric
中科院分区：
文献类型：
--
作者：
Vanhamme, Luc;Boudjeltia, Karim Zouaoui;Delporte, Cedric
髓过氧化物酶（MPO）是哺乳动物过氧化物酶家族的一员。主要表达于中性粒细胞、单核细胞和巨噬细胞中。作为活性氧化物种和自由基形成的催化剂，它有助于中性粒细胞的杀菌活性。然而，MPO失效似乎不会对受影响的个人产生重大的健康后果。这表明MPO在进化过程中可能具有支持其保存的其他功能。我们将回顾在组织特异性表达、功能和酶活性方面支持这些非规范功能的现有数据。因此，我们讨论其细胞类型特异性表达。我们回顾了它在血管生成、内皮（天）功能、免疫反应和炎症中的作用。本文综述了其在心血管疾病、癌症等临床疾病中的病理作用。
Myeloperoxidase (MPO) is a member of the mammalian peroxidase family. It is mainly expressed in neutrophils, monocytes and macrophages. As a catalyzer of reactive oxidative species and radical species formation, it contributes to neutrophil bactericidal activity. Nevertheless MPO invalidation does not seem to have major health consequences in affected individuals. This suggests that MPO might have alternative functions supporting its conservation during evolution. We will review the available data supporting these non-canonical functions in terms of tissue specific expression, function and enzymatic activity. Thus, we discuss its cell type specific expression. We review in between others its roles in angiogenesis, endothelial (dys-) function, immune reaction, and inflammation. We summarize its pathological actions in clinical conditions such as cardiovascular disease and cancer.